2013 Fiscal Year Final Research Report
Research in Kenya for the development of diagnosis of latent and active tuberculosis
| Project/Area Number |
23406011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Niigata University (2013)
Osaka City University (2011-2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAMANO Shinjiro 長崎大学, 熱帯医学研究所, 教授 (70294915)
KOBAYASHI Kazuo 国立感染症研究所, 免疫部, 部長 (20142432)
ATO Manabu 国立感染症研究所, 免疫部, 部長 (20392318)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA Masaaki 長崎大学, 熱帯医学研究所, 教授 (70124831)
KANEKO Satoshi 長崎大学, 熱帯医学研究所, 教授 (00342907)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 感染症 / 結核 / 寄生虫 / 栄養 / アフリカ |
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| Research Abstract |
Tuberculosis is deadly infectious diseases found worldwide and remains a leading public health problem. The majority of TB cases arise from latent Mycobacterium tuberculosis infection (LTBI). However the risk of LTBI and development of TB from infection is largely unknown. We conducted comprehensive health survey in TB endemic area, Kenya Africa. In this study, 627 children from schools situated in two different sites, Mbita and Kwale districts, Kenya were enrolled. And we conducted comprehensive survey including biochemical analysis of blood and detection of infections of parasitic and bacterial pathogens. We found latent antigens M. tuberculosis is a candidates for more sensitive diagnosis of LTBI and hookworm infection is a risk of Mycobacterium tuberculosis infection besides active tuberculosis.
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Research Products
(53 results)
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[Journal Article] Risk Factors and Spatial Distribution of Schistosoma mansoni Infection among Primary School Children in Mbita District, Western Kenya2014
Author(s)
Nagi S., Chadeka E., Sunahar T., Fernando Chaves L., Mutung F., Yombo KDJ., S. Kaneko, H. Ogura, Y. Ichinose, SM. Matsumoto S., Njenga S, Hashizume M., Shimada M., Hamano S
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Journal Title
PLOS Neg Trop Dis
Volume: (in press)
Peer Reviewed
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[Journal Article] Direct detection of Mycobacterium avium in environmental water and scale samples by loop-mediated isothermal amplification2014
Author(s)
Nishiuchi, Y., Tamaru, A., Suzuki, Y., Kitada, S., Maekura, R., Tateishi, Y., Niki, M., Ogura, H., and Matsumoto, S
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Journal Title
J Water Health
Volume: (in press)
Peer Reviewed
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[Journal Article] Relationship between Mycobacterium tuberculosis and hookworm infections among school children in Mbita, Kenya2014
Author(s)
Manabu I, Nagi S., Chadeka E., Mutungi F., Osada-Oka M., Ono K., Oda T., Michinori T., Ozeki Y., Dan Justin Yombo K., Okabe M., Niki M., Hirayama Y., Fukui M., Kobayashi K., M. Matsumoto, M. Shimada, S. Kaneko, H. Ogura, Y. Ichinose, SM. Njenga, S. Hamano, and S. Matsumoto
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Journal Title
J Trop Dis
Volume: (in press)
Peer Reviewed
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[Journal Article] Reactivation of immune responses against Mycobacterium tuberculosis by boosting with the CpG oligomer in aged mice primarily vaccinated with Mycobacterium bovis BCG2013
Author(s)
Taniguchi, K., T. Takii, S. Yamamoto, J. Maeyama, S. Iho, M. Maruyama, N. Iizuka, Y. Ozeki, S. Matsumoto, T. Hasegawa, Y. Miyatake, S. Itoh, and K. Onozaki
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Journal Title
Immun Ageing
Volume: 10
Pages: 25
Peer Reviewed
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[Journal Article] Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis2013
Author(s)
Osada-Oka, M., Y. Tateishi, Y. Hirayama, Y. Ozeki, M. Niki, S. Kitada, R. Maekura, K. Tsujimura, Y. Koide, N. Ohara, T. Yamamoto, K. Kobayashi, and S. Matsumoto
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Journal Title
Microbiol Immunol
Volume: 57
Pages: 30-37
Peer Reviewed
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[Journal Article] Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis2013
Author(s)
Fukuda, T., T. Matsumura, M. Ato, M. Hamasaki, Y. Nishiuchi, Y. Murakami, Y. Maeda, T. Yoshimori, S. Matsumoto, K. Kobayashi, T. Kinoshita, and Y. S. Morita
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Journal Title
Mbio
Volume: 4
Pages: e00472-00412
Peer Reviewed
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[Journal Article] Whole-Genome Sequence of the Hypervirulent Clinical Strain Mycobacterium intracellulare M.i.1982012
Author(s)
Tateishi, Y., S. Kitada, K. Miki, R. Maekura, Y. Ogura, Y. Ozeki, Y. Nishiuchi, M. Niki, T. Hayashi, K. Hirata, K. Kobayashi, and S. Matsumoto
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Journal Title
J Bacteriol
Volume: 194
Pages: 6336
Peer Reviewed
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[Journal Article] Dominant Incidence of Multidrug and Extensively Drug-Resistant Specific Mycobacterium tuberculosis Clones in Osaka Prefecture, Japan2012
Author(s)
Tamaru, A., C. Nakajima, T. Wada, Y. Wang, M. Inoue, R. Kawahara, R. Maekura, Y. Ozeki, H. Ogura, K. Kobayashi, Y. Suzuki, and S. Matsumoto
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Journal Title
PLoS One
Volume: 7
Pages: e42505
Peer Reviewed
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[Journal Article] A novel mechanism of growth phase-dependent tolerance to isoniazid in mycobacteria2012
Author(s)
Niki, M., M. Niki, Y. Tateishi, Y. Ozeki, T. Kirikae, A. Lewin, Y. Inoue, M. Matsumoto, J. L. Dahl, H. Ogura, K. Kobayashi, and S. Matsumoto
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Journal Title
J Biol Chem
Volume: 287
Pages: 27743-27752
Peer Reviewed
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[Journal Article] A Histone-Like Protein of Mycobacteria Possesses Ferritin Superfamily Protein-Like Activity and Protects against DNA Damage by Fenton Reaction2011
Author(s)
Takatsuka, M., M. Osada-Oka, E.F. Satoh, K. Kitadokoro, Y. Nishiuchi, M. Niki, M. Inoue, K. Iwai, T. Arakawa, Y. Shimoji, H. Ogura, K. Kobayashi, A. Rambukkana, and S. Matsumoto
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Journal Title
PLoS One
Volume: 6
Pages: e20985
Peer Reviewed
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[Journal Article] Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway2011
Author(s)
Kasahara, E., A. Sekiyama, M. Hori, K. Hara, N. Takahashi, M. Konishi, E. F. Sato, S. Matsumoto, H. Okamura, and M. Inoue
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Journal Title
FEBS Lett
Volume: 585
Pages: 2263-2268
Peer Reviewed
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[Presentation] ケニア共和国における, 学生の潜在性結核菌感染と様々な寄生虫感染2012
Author(s)
Inoue M., S. Nagi, E. Faith, M. Osada-Oka, K. Ono, Y. Ozeki, M. Niki, K. Kobayashi, M. Matsumoto, M. Shimada, S. Kaneko, Y. Ichinose, S. Njenga, S. Hamano, and S. Matsumoto
Organizer
第53回日本熱帯医学会大会
Place of Presentation
北海道
Year and Date
20120905-06
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