2014 Fiscal Year Final Research Report
Genetic contribution of HLA-A alleles for the pathogenesis of Behcet disease in East Asia
| Project/Area Number |
23406031
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKEUCHI FUJIO 東京大学, 医学部附属病院, 講師 (70154979)
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| Co-Investigator(Kenkyū-buntansha) |
KABURAKI Toshikatsu 東京大学, 医学部附属病院, 講師 (70343126)
HARIHARA Shinji 東京大学, 大学院理学系研究科, 助教 (40198932)
NOGUCHI Hiroshi 静岡県立大学, 薬学部, 教授 (60126141)
KUWATA Shoji 帝京大学, ちば総合医療センター, 教授 (00241993)
HAGINO Noboru 帝京大学, ちば総合医療センター, 講師 (40466769)
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| Research Collaborator |
PARK Myoung Hee 韓国, ソウル大学・医学部, 教授
SONG Yeong Wook 韓国, ソウル大学・医学部, 教授
YU Chia-Li 台湾, 台湾大学・医学部, 教授
WORAWIT Louthrenoo タイ, チェンマイ大学・医学部, 教授
SUPOT Hannongbua タイ, チュラロンコン大学・理学部, 教授
SA-NGA Pattanakitsul タイ, マヒドン大学・医学部, 准教授
PHAN Thi Hoan ベトナム, ハノイ医科大学・医学部, 准教授
AMR H Sawalha アメリカ, ミシガン大学・医学部, 准教授
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | ベーチェット病 / 東アジア / 疾患感受性遺伝子 / HLA / IL23R / 民族差 / 三次元構造 / MICA |
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| Outline of Final Research Achievements |
The contribution of HLA and the IL23R-IL12RB area (rs1495966)) as the genetic factors for the pathogenesis of Behcet’s disease (BD) was examined. In Korean BD the association of HLA-A*2601 allele with the ocular involvement was observed (p<0.05), as the same as in Japanese BD. Moreover, the A*0207 allele was associated with the skin involvement in Korean BD (p<0.05). In Japanese, the increase of A*0207 was observed in the patients without both A*2601 and B*5101 (OR=2.82). The A*0207 was also increased in Thai patients without the both alleles. These findings suggest the possibility that the A*0207 allele is the third susceptibility allele of BD. On the other hand, the rs1495866 was associated with BD independently from HLA (p<0.05). The calculation of the free energy charge for the binding between HLA and MICA-TM peptide (AAAAAIFVI) indicated that the HLA alleles (A*2601 & B*5101) associated with BD bind strongly by 7-11 Kcal/mol comparing to the alleles without association.
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| Free Research Field |
内科学、リウマチ学、臨床遺伝学
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