2013 Fiscal Year Final Research Report
Study on new regulatory mechanism for the function of myosin in neurons
| Project/Area Number |
23500386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
YAGI Hideshi 兵庫医科大学, 医学部, 准教授 (10303372)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Makoto 大阪大学, 大学院・連合小児発達研究科, 教授 (10222019)
KURODA Kazuki 福井大学, 医学部, 助教 (60557966)
KOMADA Munekazu 愛知学院大学, 歯学部, 助教 (90523994)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経細胞 / 細胞骨格 / アクチン線維 / ミオシン |
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| Research Abstract |
FILIP has a role in the development of central nervous system through the binding of filamin A that is one of the actin-binding proteins. We investigated the additional function of FILIP on the neuronal morphology in this study. We observed that the expression of FILIP was observed in the limited region of the adult brain. We found that FILIP bound to one of the non-muscle type myosin and altered the subcellular distribution of it. We disclosed that FILIP influenced on the morphology of the excitatory neurons. Our findings suggested that FILIP altered the morphology of neurons through the binding of the myosin. These results indicate that FILIP regulated actomyosin dynamics that have a role on the neuronal morphology.
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[Presentation] FILIP is involved in the morphological control of dendritic spine through actomyosin Regulation2012
Author(s)
Hideshi Yagi, Kazuki Kuroda, Min-Jue Xie, Hiroshi Ikeda, Tokuichi Iguchi, Takashi Nagano, Munekazu Komada, Kazuyuki Murase, Masaru Okabe, Koichi Noguchi, Makoto Sato
Organizer
Neuroscience 2012 (SOCIETY for NEUROSIENCE)
Place of Presentation
New Orleans, USA
Year and Date
2012-10-16
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[Presentation] FILIP-related molecule controls spine maturation in the hippcampal neuron via non-muscle myosin llb2012
Author(s)
Kuroda, K., Yagi, H., Xie, M.-J., Oka, Y., Iguchi, T., and Sato, M
Organizer
The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry / 55th Annual Meeting of the Japanese Society for Neurochemistry
Place of Presentation
神戸市
Year and Date
2012-09-29
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[Presentation] FILIP によるアクチンミオシン調節能の棘突起動態変化への関与2012
Author(s)
Hideshi Yagi, Kazuki Kuroda, Min-Jue Xie, Takashi Nagano, Hiroshi Ikeda, Tokuichi Iguchi, Kazuyuki Murase, Masaru Okabe, and Makoto Sato
Organizer
第35回日本神経科学大会
Place of Presentation
名古屋市(名古屋国際会議場)
Year and Date
2012-09-19
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