2013 Fiscal Year Final Research Report
Study on cellular diversity and treatment-sensitive/resistant fraction in IDH1-mutant gliomas
| Project/Area Number |
23500429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyushu University |
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Principal Investigator |
SATOSHI Suzuki 九州大学, 医学(系)研究科(研究院), 准教授 (90294917)
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| Co-Investigator(Renkei-kenkyūsha) |
IWAKI Toru 九州大学, 大学院・医学研究院神経病理学 (40221098)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳腫瘍 / グリオーマ / イソクエン酸脱水素酵素１ / 免疫組織化学 |
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| Research Abstract |
To evaluate heterogeneity among cells in glioma tissues, we performed immunohistochemistry against mutant isocitrate dehydrogenase 1, a marker for a representative gene alteration in gliomas, together with other glioma markers (MAP-2e, p53, DCX, nestin), a proliferation marker (Ki-67) and lineage-specific markers (GFAP, Olig2, Iba-1). The results suggest existence of different tumor cell components with different genetic backgrounds and/or reactive components with a similar biological behavior to tumor cells even in one same tumor tissue. The findings would lead to the identification of tumor initiating cells, potentially a genuine therapeutic target, in tissue sections.
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