2013 Fiscal Year Final Research Report
Participation of LRP4 postsynaptic density protein in higher nerve function
| Project/Area Number |
23500441
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Tatsuo 信州大学, 医学系研究科, 教授 (80162965)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAGAMI Hiroyuki 北里大学, 医学部, 教授 (90261528)
HARA Yoshinobu 北里大学, 医学部, 助教 (40558467)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経可塑性 / シナプス / 合指多指症 / 歯数過剰 / 不正咬合 / 腎臓欠失 / 羊水過多 / アクアポリン |
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| Research Abstract |
Lrp4 KO mice died at birth due to their inability to breathe. The mutant mice displayed syndactyly or polydactyly and 30% (29/97) bilateral and 53% (51/97) unilateral kidney agenesis. At E18.5 the mutant lungs were reduced in size (to 88%) compared with their wild type and heterozygote counterparts, and the mutant fetus had a 2.5-times greater volume of amniotic fluid than the controls. Although the major source of fluid entering the amniotic cavity is fetal urine, the polyhydramnios were observed in the mutant fetus with bilateral kidney agenesis. The system of amniotic fluid production may be different between human and mice. The two primary routes of amniotic fluid removal are fetal swallowing and absorption from the amniotic cavity into the fetal blood vessels of the chorionic plate. The mutant fetus displayed failure to swallowing, and the expression of AQP9 and 1 were reduced in fetal membrane and placenta, respectively. We also observed Lrp4 was expressed in reactive astrocyte.
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Research Products
(3 results)
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[Remarks] 棚橋浩, 原芳信, Wei-Dong Yao, 阪上洋行, 鈴木龍雄, シナプス後肥厚部に発現するLRP4 (LDL-receptor-related protein 4) の高次神経機能への関与, 冲中記念成人病研究研究所年報, 38, 2012, pp.58-59
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[Remarks] 棚橋浩, 脳で働く分子を探る, 第2回疾患予防医科学キックオフセミナー,日本科学未来館(東京), 11月18日2012年
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[Remarks] 棚橋浩, シナプス後肥厚部に発現するLRP4 (LDL-receptor-related protein 4) の高次神経機能への関与, 第37 回冲中記念成人用研究所 研究報告会, 虎ノ門病院(東京), 3月3日2012年
