2013 Fiscal Year Final Research Report
Functional analysis of CHD family in neural stem cells and glioma stem cells
| Project/Area Number |
23500453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Keio University |
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Principal Investigator |
OHTA SHIGEKI 慶應義塾大学, 医学部, 講師 (20365406)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
FUKAYA Raita 慶應義塾大学, 医学部, 研究員 (60348670)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 再生医療 / 神経幹細胞 / グリオーマ / 癌幹細胞 |
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| Research Abstract |
The expression of CHD7, which is upregulated by MIF and Pax6, has been shown in mouse neural stem cells, with Hes5 and N-Myc identified as downstream signaling molecules. CHD7 regulates cell proliferation and stemness maintenance in mouse neural stem cells, and it also plays a role in the proliferation of human ES cell-derived neural stem cells. CHD7 mutant fetal mouse brains had fewer Tbr2/Ki67 double-positive cells compared to wildtype brains, showing that CHD7 affects neurogenesis in the early developmental mouse brain. Furthermore, CHD7 was highly expressed in glioma stem cells compared to normal astrocytes, and it was shown to regulate cell proliferation, indicating that CHD7 is a promising therapeutic target for the treatment of gliomas.
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