2013 Fiscal Year Final Research Report
Functional maturation of the control of the mammalian spinal locomotor network
| Project/Area Number |
23500460
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOGANEZAWA Tadachika 筑波大学, 医学医療系, 助教 (80431691)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経回路 / 歩行 / 運動 / マウス / 脊髄 |
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| Research Abstract |
In this study we used genetically-modified mice that show abnormal gait to investigate the function and maturation of the locomotor network in the spinal cord especially how it is controlled by the supraspinal structures. Our findings suggest that the corticospinal tract plays little role in the development of the spinal locomotor network and that a population of EphA4-positive spinal excitatory neurons play a significant role in the normal development of the mammalian locomotor circuit.
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