2013 Fiscal Year Final Research Report
Live-cell imaging to monitor X-chromosome reactivation and stem cell reasearch
| Project/Area Number |
23500492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOBAYASHI Shin 東京医科歯科大学, 難治疾患研究所, 非常勤講師 (10397664)
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| Co-Investigator(Kenkyū-buntansha) |
OKABE Masaru 大阪大学, 微生物病研究所, 教授 (30089875)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 遺伝子組換え動物 / X染色体不活性化 / イメージング |
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| Research Abstract |
In stem cell research, reactivation of X chromosomes is recognized as an indicator of the pluripotent grand state of stem cells. However, there is no report of the monitoring method on this phenomenon. Therefore, we attempt to develop a novel method to monitor this phenomenon based on a live-imaging technique. This method would help us to understand the reprogramming process at the molecular level. The outcomes of this search will have considerable impact in medical care.
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