2013 Fiscal Year Final Research Report
The development and demonstration of methodology to elucidate the sugar chain function and glycosyltransferase knockout mouse phenotype.
| Project/Area Number |
23500493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ASANO Masahide 金沢大学, 学際科学実験センター, 教授 (50251450)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 発生工学 |
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| Research Abstract |
From behavioral analyses of beta 1, 4-galactosyltransferase-2 (B4GalT-2) gene knockout mice, we have found that galactose sugar chains synthesized by B4GalT-2 have a function in the central nervous system. Therefore, we tried to generate novel knock-in mice in order to identify cells and brain regions where B4GalT-2 is involved, to obtain clues identifying functional carbohydrate molecules. We constructed two kinds of targeting vectors, one for monitoring B4GalT-2 expression by lacZ gene and the other for recovering B4GalT-2 expression conditionally. We are trying to isolate desired ES clones.
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Research Products
(2 results)
