2013 Fiscal Year Final Research Report
Improvement of BNCT effect by control of intracellular distribution
| Project/Area Number |
23500544
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka City University |
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Principal Investigator |
NAGASAKI Takeshi 大阪市立大学, 工学(系)研究科(研究院), 教授 (30237507)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Masaya 大阪市立工業研究所, 電子材料研究部, 研究員 (90416363)
AZUMA Hideki 大阪市立大学, 大学院・工学研究, 講師 (80311918)
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| Co-Investigator(Renkei-kenkyūsha) |
MASUNAGA Shin-ichiro 京都大学, 原子炉実験所, 教授 (80238914)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ホウ素中性子捕捉療法 / ホウ素クラスター / 核局在性 / 抗がん性 / ターゲッティング |
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| Research Abstract |
Kojic acid possesses a whitening ability to melanocytes. This fact suggests that kojic acid could work as effective ligand for melanoma-targeting. We used kojic acid-carborane conjugate (CKA). Because CKA shows little water-solubility, various cyclodextrins were used as a solubilizer. As the inclusion complex of hydroxypropyl-beta-cyclodextrin (HP-b-CD) provided the highest concentration of CKA solution, herein, the CKA/HP-b-CD complex was estimated as a boron carrier for melanoma-targeting BNCT. In B16BL6 cells, CKA was interestingly localized in the nucleus. When 1500 ppm of 10B solutions were used, average survival rate were 19 and 22 days with L-BPA/fructose and CKA/HP-b-CD complex, respectively. Moreover, long survival rates (25 days) were observed with 4500 ppm of 10B solutions of CKA/HP-b-CD complex. Kojic ac-id-appended carborane is promising to be an efficient boron agent toward melanoma BNCT.
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[Journal Article] Tumor growth suppression by gadolinium-neutron capture therapy using gadolinium-entrapped liposome as gadolinium delivery agent2013
Author(s)
N. Dewia, H. Yanagie, H. Zhu, K. Demachi, A. Shinohara, K. Yokoyama, M. Sekino, Y. Sakurai, Y. Morishita, N. Iyomoto, T. Nagasaki, Y. Horiguchi, Y. Nagasaki, J. Nakajima, M. Suzuki, K. Ono, K. Kakimi, H. Takahashi
Volume
Vol. 67
Pages
451-457
DOI
Peer Reviewed
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[Journal Article] Tumor Accumulation of ・-Poly-Lysines-Based Polyamines Conjugated with Boron Clusters2011
Author(s)
M. Umano, K. Uechi, T. Uriuda, S. Murayama, H. Azuma, A. Shinohara, Y. Liu, K. Ono, M. Kirihata, H. Yanagie, T. Nagasaki
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Journal Title
Appl. Radiat. Isot
Volume: Vol. 69
Pages: 1765-1767
Peer Reviewed
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