Development of Diagnosis Device for Alzheimer's Disease Using Amyloid beta Fibrillization Promoting Peptide

2013 Fiscal Year Final Research Report

• Project/Area Number: 23500571
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Konan University
• Principal Investigator: FUJII SATOSHI 甲南大学, フロンティアサイエンス学部, 教授 (80271518)
• Project Period (FY): 2011 – 2013
• Keywords: アルツハイマー型認知症 / アミロイドβ / プロテインチップ / 電気化学 / センサー / 水晶振動子マイクロバランス法

Outline of Final Research Achievements

Amyloid beta peptide (A beta) is a potential biomarker to evaluate the risk of Alzheimer's disease. Our purpose in this study was to develop a preclinical diagnostic device for Alzheimer's disease with ultra high sensitivity, ease, and high-through put, and at low cost. Using an A beta aggregation promoting peptide which was developed by us, we can detect ~10 nM of A beta quantitatively within 1 hour. We are now trying to improve the sensitivity to detect plasma A beta and put it to practical use.

Free Research Field

総合領域