Effects of daily physical activity with bone mass in hemodialysis patients

2013 Fiscal Year Final Research Report

• Project/Area Number: 23500614
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kitasato University
• Principal Investigator: MATSUNAGA Atsuhiko 北里大学, 医療衛生学部, 教授 (00286387)
• Co-Investigator(Kenkyū-buntansha): WATANABE Hiroyuki 北里大学, 医療衛生学部, 講師 (40348602) ; KIMURA Masahiko 北里大学, 医療衛生学部, 講師 (20458748) ; KITAGAWA Jun 北里大学, 一般教育部, 准教授 (80260529)
• Project Period (FY): 2011 – 2013
• Keywords: リハビリテーション / 骨量 / 身体活動 / 慢性腎臓病 / 血液透析 / 運動療法

Research Abstract

Purpose: This study aimed to determine whether daily physical activity is associated with bone mass in hemodialysis (HD) patients. Methods: In cross-sectional Study 1, 150 HD outpatients undergoing maintenance HD 3 times a week were recruited. Clinical characteristics and biochemical parameters were measured. Bone mass was assessed by quantitative ultrasound measurement at the calcaneus. Physical activity (steps) was measured using an accelerometer. In 2-year follow-up Study 2, participants were divided into two subgroups according to physical activity based on results from Study 1 (more than 5,000 steps per day or not). Results: Adjusted multiple regression analysis in Study 1 indicated that physical activity was significantly associated with bone mass for each sex. ANOVA showed that changes in bone mass were significantly different between the two subgroups for each sex in Study 2. Conclusion: Decreased daily physical activity is strongly associated with bone loss in HD patients.

Research Products

• [Journal Article] Relationship between lower extremity muscle strength and all-cause mortality in Japanese patients undergoing dialysis (2014)
  • Author(s): Matsuzawa R, Matsunaga A, Wang G, Yamamoto S, Kutsuna T, Ishii A, Abe Y, Yoneki K, Yoshida A, Takahira N
  • Journal Title: Physical therapy Volume: (in press)
  • Peer Reviewed
• [Journal Article] Association of habitual physical activity measured by an accelerometer with high-density lipoprotein cholesterol level in maintenance hemodialysis patients (2013)
  • Author(s): Matsuzawa R, Matsunaga A, Kutsuna T, Ishii A, Abe Y, Yoneki K, Harada M, Takeuchi Y, Yoshida A, Takahira N
  • Journal Title: The Scientific World Journal Pages: 1-6
  • Peer Reviewed
• [Journal Article] Habitual physical activity measured by accelerometer and survival in maintenance hemodialysis patients (2012)
  • Author(s): Matsuzawa R, Matsunaga A, Wang G, Kutsuna T, Ishii A, Abe Y, Takagi Y, Yoshida A, Takahira N
  • Journal Title: Clinical Journal of the American Society of Nephrology Volume: 7 Pages: 2010-6
  • Peer Reviewed
• [Presentation] Association of daily physical activity with bone mass in hemodialysis patients (2013)
  • Author(s): Yoneki K, Matsunaga A, Kitagawa J, Matsuzawa R, Ishii A, Abe Y, Harada M, Takeuchi Y, Kamata K
  • Organizer: American Society of Nephrology(KIDNEY WEEK 2013)
  • Place of Presentation: Atlanta, Georgia, USA
  • Year and Date: 20131105-10
• [Presentation] Effects of walking ability on risk of hospitalization for cardiocerebrovascular events in hemodialysis patients (2013)
  • Author(s): Abe Y, Matsunaga A, Matsuzawa R, Ishii A, Yoneki K, Harada M, Kutsuna T, Takeuchi Y, Yoshida A, Kamata K
  • Organizer: American Society of Nephrology (KIDNEY WEEK 2013)
  • Place of Presentation: Atlanta, Georgia, USA
  • Year and Date: 20131105-10
• [Presentation] Association of physical activity with HDL-C level in hemodialysis patients (2013)
  • Author(s): Matsuzawa R, Matsunaga A, Ishii A, Abe Y, Yoneki K, Harada M, Takagi Y, Yoshida A, Kamata K, Takahira N
  • Organizer: American Society of Nephrology (KIDNEY WEEK 2013)
  • Place of Presentation: Atlanta, Georgia, USA
  • Year and Date: 20131105-10
• [Presentation] Motor function and activities of daily living among ambulatory patients undergoing maintenance hemodialysis (2013)
  • Author(s): Harada M, Abe Y, Matsuzawa R, Ishii A, Yoneki K, Shigeta K, Abe H, Toda N, Kimura M, Shimizu S, Watanabe H, Matsunaga A
  • Organizer: The 6th Asia-Western Pacific Regional Congress of the World Confederation for Physical Therapy
  • Place of Presentation: Taichung, Taiwan
  • Year and Date: 20130905-09
• [Presentation] Effects of physical activity on risk of hospitalization of cardio-cerebrovascular events in hemodialysis patients, European Renal Association-European-Dialysis-Transp lant-Association (ERA-EDTA) (2013)
  • Author(s): Matsuzawa R, Matsunaga A, Ishii A, Abe Y, Yoneki K, Harada M, Takagi Y, Yoshida A, Takahira N
  • Organizer: 50th Congress
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 20130518-21
• [Presentation] Determinants of decreased walking speed among patients undergoing ambulatory hemodialysis (2012)
  • Author(s): Abe Y, Matsunaga A, Matsuzawa R, Ishii A, Minowa T, Yoneki K, Kutsuna T, Shigeta K, Kamata K
  • Organizer: American Society of Nephrology (KIDNEY WEEK 2012)
  • Place of Presentation: San Diego, USA
  • Year and Date: 20121030-1104
• [Presentation] Lower-extremity muscle strength and survival in hemodialysis patients : A prospective cohort study (2012)
  • Author(s): Matsuzawa R, Matsunaga A, Ishii A, Abe Y, Minowa T, Yoneki K, Takagi Y, Yoshida A, Kamata K, Takahira N
  • Organizer: American Society of Nephrology (KIDNEY WEEK 2012)
  • Place of Presentation: San Diego, USA
  • Year and Date: 20121030-1104
• [Presentation] 下肢筋力の低下は血液透析患者の死亡リスクを増大させる~7年間の前向きコホート研究 (2012)
  • Author(s): 松沢良太, 松永篤彦, 石井玲, 阿部義史, 箕輪俊也, 清水絵里香, 米木慶, 高木裕, 吉田照, 高平尚伸
  • Organizer: 第57回日本透析医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 20120622-24
• [Presentation] 血液透析患者が移動時に自覚する困難さの有無を規定する因子の検討 (2012)
  • Author(s): 箕輪俊也, 松永篤彦, 松沢良太, 志真奈緒子, 石井玲, 室内直樹, 阿部義史, 高木裕, 吉田照
  • Organizer: 第57回日本透析医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 20120622-24
• [Presentation] 血液透析患者の死体活動量低下には行動変容ステージが関与する (2012)
  • Author(s): 松沢良太, 松永篤彦, 石井玲, 室内直樹, 阿部義史, 箕輪俊也, 清水絵里香, 志真奈緒子, 米木慶, 吉田照, 高平尚伸
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
  • Year and Date: 20120525-27
• [Presentation] 末梢神経障害の併存が維持血液透析患者のバランス機能に及ぼす影響 (2012)
  • Author(s): 阿部義史, 松永篤彦, 松沢良太, 室内直樹, 箕輪俊也, 石井玲, 志真奈緒子, 清水絵里香, 米木慶, 吉田照
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
  • Year and Date: 20120525-27
• [Presentation] 維持血液透析患者が歩行時に困難感を生じないために維持すべき運動機能について (2012)
  • Author(s): 箕輪俊也, 忽那俊樹, 松沢良太, 志真奈緒子, 石井玲, 室内直樹, 阿部義史, 米木慶, 清水絵里香, 松永篤彦
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
  • Year and Date: 20120525-27
• [Presentation] 維持血液透析患者の日常の身体活動量は骨密度と密接に関連している (2012)
  • Author(s): 米木慶, 松永篤彦, 北川淳, 松沢良太, 石井玲, 阿部義史, 箕輪俊也, 吉田照
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
  • Year and Date: 20120322-24
• [Presentation] 維持血液透析患者の機能的移動能力の低下には末梢神経障害が強く関与している (2012)
  • Author(s): 阿部義史, 松永篤彦, 松沢良太, 石井玲, 箕輪俊也, 米木慶, 高木裕, 吉田照
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
  • Year and Date: 20120322-24
• [Presentation] 維持血液透析患者における移動動作時の困難さの出現には日常の身体活動量が関与する (2012)
  • Author(s): 箕輪俊也, 松永篤彦, 松沢良太, 石井玲, 阿部義史, 米木慶, 吉田照
  • Organizer: 第3回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 宇都宮
  • Year and Date: 20120322-24
• [Presentation] 副甲状腺機能が正常範囲にある維持血液透析患者の骨密度は身体活動量を管理することで低下を予防できる (2012)
  • Author(s): 阿部義史, 松永篤彦, 松沢良太, 室内直樹, 箕輪俊也, 石井玲, 清水絵里香, 志真奈緒子, 米木慶, 吉田照
  • Organizer: 第2回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-20
• [Presentation] Relationship between bone mineral density and physical activity in daily life in patients undergoing maintenance hemodialysis (2011)
  • Author(s): Abe Y, Matsunaga A, Matsushima S, Kutsuna T, Matsuzawa R, Hemmi F, Murouchi N, Minowa T, Yamamoto S, Hayashi Y, Nemoto S, Motohashi S, Takagi Y, Yoshida A, Takahira N, Masuda T
  • Organizer: 16th World Physical Therapy International Congress
  • Place of Presentation: Amsterdam, Holland
  • Year and Date: 2011-06-20
• [Presentation] Effects of daily physical activity time on walking ability in ambulatory hemodialysis patients : a 3-year follow-up study (2011)
  • Author(s): Matsuzawa R, Matsunaga A, Kutsuna T, Yamamoto S, Hemmi F, Abe Y, Murouchi N, Takagi Y, Motohashi S, Yoshida A, Takahira N, Masuda T
  • Organizer: 16th World Physical Therapy International Congress
  • Place of Presentation: Amsterdam, Holland
  • Year and Date: 2011-06-20