The development of anti-atherogenic exercise program by regulating skeletal muscle inflammation

2013 Fiscal Year Final Research Report

• Project/Area Number: 23500620
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Juntendo University
• Principal Investigator: SHIMADA Kazunori 順天堂大学, 医学(系)研究科(研究院), 准教授 (60327814)
• Co-Investigator(Renkei-kenkyūsha): NAITO Hisashi 順天堂大学, スポーツ健康科学研究科, 教授 (70188861) ; IWABUCHI Kazuhisa 順天堂大学, 医療看護学研究科, 教授 (10184897)
• Project Period (FY): 2011 – 2013
• Keywords: 動脈硬化 / マクロファージ / 骨格筋

Research Abstract

M1 macrophages, but not M0 or M2 macrophages, which characteristically respond to oxLDL, were associated with NF-kB signaling. M1 was dominant in aneurysmal lesions and peritoneal macrophages. Inflammatory cells were detected in skeletal muscles in mice with atherosclerotic formation. Voluntary exercise as well as forced exercise reduced atherosclerotic formation via inhibition of macrophage accumulation and inflammatory reaction. Cardiac rehabilitation improved muscle mass, muscle strength, and exercise tolerance. Exercise capacity was associated with clinical prognosis. These results suggested that maintaining physical activity may ameliorate the initiation and progression of atherosclerosis through anti-inflammatory effects.

Research Products

• [Journal Article] High molecular weight adiponectin level is associated with atherogenic lipoprotein profiles in healthy Japanese males (2014)
  • Author(s): Miyazaki T, Hiki M, Shimada K, Kume A, Kiyanagi T, Sumiyoshi K, Daida H
  • Journal Title: J Atheroscler Thromb Volume: (in press)
  • Peer Reviewed
• [Journal Article] Effect of cardiac rehabilitation on muscle mass, muscle strength, and exercise tolerance in diabetic patients after coronary artery bypass grafting (2013)
  • Author(s): Nishitani M, Shimada K, Sunayama S, Masaki Y, Kume A, Fukao K, Sai E, Yamashita H, Ohmura H, Onishi T, Shioya M, Sato H, Shimada A, Yamamoto T, Amano A, Daida H
  • Journal Title: J Cardiol Volume: 61 Pages: 216-221
  • DOI: 10.1016/j.jjcc.2012.11.004
  • Peer Reviewed
• [Journal Article] Diversity and plasticity of monocyte subsets : Tipping the delicate balance involved in pathogenesis of atherosclerosis (2012)
  • Author(s): Shimada K
  • Journal Title: Circ J Volume: 76 Pages: 2331-2332
  • DOI: 10.1253/circj.CJ-12-1052
  • Peer Reviewed
• [Journal Article] Effects of voluntary exercise on the progression of atherosclerotic lesions in apolipoprotein E-deficient mice : Protective role against vascular inflammation (2012)
  • Author(s): Fukao K, Shimada K, Naito H, Sumiyoshi K, Inoue N, Iesaki T, Yasue T, Toyoda S, Yoshihara T, Kume A, Kiyanagi T, Hiki M, Hirose K, Matsumori R, Ohsaka H, Sai E, Yamashita H, Miyazaki T, Itoh S, Tada N, Daida H
  • Journal Title: Inangural International Academy of Sportology Proceeding Pages: 105-110
• [Journal Article] Impact of diabetes on muscle mass, muscle strength, and exercise tolerance in patients after coronary artery bypass grafting (2011)
  • Author(s): Nishitani M, Shimada K, Sunayama S, Masaki Y, Kume A, Fukao K, Sai E, Yamashita H, Ohmura H, Onishi T, Shioya M, Sato H, Shimada A, Yamamoto T, Amano A, Daida H
  • Journal Title: J Cardiol Volume: 58 Pages: 173-180
  • DOI: 10.1016/j.jjcc.2011.05.001
  • Peer Reviewed
• [Journal Article] Different responses to oxidized low-density lipoproteins in human polarized macrophages (2011)
  • Author(s): Hirose K, Iwabuchi K, Shimada K, Kiyanagi T, Iwahara C, Nakayama H, Daida H
  • Journal Title: Lipids Health Dis Volume: 10 Pages: 1
  • DOI: 10.1186/1476-511X-10-1
  • Peer Reviewed
• [Journal Article] 高齢冠動脈疾患患者における維持期心臓リハビリテーションの臨床的有用性 (2011)
  • Author(s): 島田和典, 大西朋, 正木克由規, 西谷美帆, 深尾宏祐, 久米淳美, 代田浩之
  • Journal Title: Ther Res Volume: 32 Pages: 704-709
  • Peer Reviewed
• [Presentation] Prognostic impact of exercise tolerance and muscle strength in diabetic patients after offpump coronary artery bypass grafting (2014)
  • Author(s): Yokoyama M, Shimada K, Kume A, Masaki Y, Fukao K, Sai E, Yoshihara T, Tsuruta R, Yamamoto T, Amano A, Daida H
  • Organizer: 78th Annual Meeting of JCS
  • Place of Presentation: Tokyo
  • Year and Date: 20140300
• [Presentation] Omega-3 polyunsaturated fatty acids suppresses development of abdominal aortic aneurysm in apoE-deficient mice by shifting the balance of macrophages from M1 to M2 (2013)
  • Author(s): Yoshihara T, Shimada K, Fukao K, Sai E, Alshahi H, Miyazaki T, Daida H
  • Organizer: American Heart Association Scientific Session 2013
  • Place of Presentation: Dallas
  • Year and Date: 20131116-20
• [Presentation] Cardiac Rehabilitation in Post CABG Patients with Coronary Risk Factors (2013)
  • Author(s): Shimada K, Yokoyama M, Masaki M, Kume A, Fukao K, Sai E, Yoshihara T, Sato H, Sunayama S, Tsuruta R, Yamamoto T, Amano A, Daida H
  • Organizer: Circ J
  • Year and Date: 20130000
• [Presentation] 動脈硬化モデルマウスにおける自発的運動とレニンアンジオテンシン系阻害薬の併用効果 (2013)
  • Author(s): 吉原琢磨, 島田和典, 深尾宏祐, 蔡榮龍, 大坂裕通, 宮崎哲郎, 代田浩之
  • Organizer: 第45回日本動脈硬化学会総会プログラム・抄録集
  • Place of Presentation: 新宿東京
  • Year and Date: 2013-07-19
• [Presentation] The levels of Inflammatory Cytokines in Peripheral Blood Mononuclear Cells in Patients with Acute Coronary Syndrome (2013)
  • Author(s): Shahi HA, Shimada K, Sai E, Yoshihara T, Miyazaki T, Miyauchi K, Daida H
  • Organizer: The 45th Annual Scientiic Meeting of the Japan Atherosclerosis Society
  • Place of Presentation: Shinjyku, Tokyo
  • Year and Date: 2013-07-19
• [Presentation] オフポンプ冠動脈バイパス術後患者における心臓リハビリテーション開始時の運動耐容能と長期予後との関連 (2013)
  • Author(s): 横山美帆, 島田和典, 砂山聡, 正木克由規, 久米淳美, 深尾宏祐, 蔡栄龍, 吉原琢磨, 大村寛敏, 塩谷みき , 北田友治, 佐藤裕之, 鶴田亮, 山本平, 天野篤, 代田浩之
  • Organizer: 第19回日本心臓リハビリテーション学会学術総会
  • Place of Presentation: 仙台, 宮城
  • Year and Date: 2013-07-14
• [Presentation] 外来心臓リハビリテーション継続における当院でのグループプログラムの実際と結果 (2013)
  • Author(s): 塩谷みき , 島田和典, 横山美帆, 正木克由規, 久米淳美, 深尾宏祐, 蔡栄龍, 吉原琢磨, 北田友治, 佐藤裕之, 天野篤, 河合祥雄, 代田浩之
  • Organizer: 第19回日本心臓リハビリテーション学会学術総会
  • Place of Presentation: 仙台, 宮城
  • Year and Date: 2013-07-14
• [Presentation] 持久的運動の種目による運動耐容能と循環器系バイオマーカーとの関連 (2013)
  • Author(s): 深尾宏祐, 島田和典, 内藤久士, 河合祥雄, 形本静夫, 宮崎哲朗, 久米淳美, 横山美帆, 比企誠, 蔡榮龍, 大坂裕通, 吉原琢磨, 代田浩之
  • Organizer: 第19回日本心臓リハビリテーション学会学術総会
  • Place of Presentation: 仙台, 宮城
  • Year and Date: 2013-07-14
• [Presentation] CABG術後患者における心臓リハビリテーション : 筋量・筋力・運動耐容能に対する糖尿病の影響 (2012)
  • Author(s): 島田和典, 西谷美帆, 正木克由規, 久米淳美, 深尾宏祐 蔡栄龍, 吉原琢磨, 大村寛敏, 塩谷みき, 砂山聡, 佐藤裕之, 山本平, 天野篤, 代田浩之
  • Organizer: 第26回日本冠疾患学会学術集会合同パネルディスカッション2. CABG/PCI後の心臓リハビリとOptimal Medical Therapy (OMT)Optimal Medical Therapy (OMT)
  • Year and Date: 20121200
• [Presentation] 高齢冠動脈バイパス術後患者における糖尿病の影響 : 心臓リハビリテーション前後の運動耐容能・筋力・筋肉量の比較 (2012)
  • Author(s): 西谷美帆, 島田和典, 砂山聡, 正木克由規, 久米淳美, 深尾宏祐, 蔡栄龍, 吉原琢磨, 大村寛敏, 塩谷みき, 佐藤裕之, 山本平, 天野篤, 代田浩之
  • Organizer: 日本心臓病学会誌7巻
  • Year and Date: 20120800
• [Presentation] Effects of cardiac rehabilitation on muscle mass, muscle strength and exercise tolerance, in diabetic patients after coronary artery bypass grafting (2012)
  • Author(s): Nishitani M, Shimada K, Sunayama S, Masaki Y, Kume A, Fukao F, Sai E, Ohmura H, Sato H, Yamamoto T, Amano A, Daida H
  • Organizer: 76th Annual Meeting of JCS
  • Place of Presentation: Fukuoka
  • Year and Date: 20120300
• [Presentation] Combination therapy of voluntary exercise with aliskiren had additive effects on atherosclerotic lesion formation in apolipoprotein E-deficient mice (2012)
  • Author(s): Fukao K, Shimada K, Yoshihara T, Sai E, Inoue N, Toyoda S, Iesaki T, Miyazaki T, Kume A, Kiyanagi T, Hiki M, Hirose K, Matsumori R, Ohsaka H, Masuda H, Daida H
  • Organizer: 76th Annual Meeting of JCS
  • Place of Presentation: Fukuoka
  • Year and Date: 20120300
• [Presentation] Impact of diabetes on muscle mass, muscle strength, and exercise tolerance in elderly patients after coronary artery bypass grafting (2012)
  • Author(s): Nishitani M, Shimada K, Kume A, Fukao K, Sai E, Ohmura H, Onishi T, Shioya M, Sato H, Amano A, Daida H
  • Organizer: EuroPREVENT 2012
  • Place of Presentation: Dublin. Ireland
  • Year and Date: 20120000
• [Presentation] 糖尿病とメ タ ボリックシンドローム症例における心臓リハビリテーション (2012)
  • Author(s): 西谷美帆, 島田和典, 深尾宏祐, 正木克由 規, 久米淳美 , 蔡栄龍, 吉原琢磨, 大西朋 , 塩谷みき , 砂山聡, 天野篤, 代田浩之
  • Organizer: 第18回日本心臓リハビリテーション学会学術総会
  • Place of Presentation: 大宮埼玉
  • Year and Date: 2012-07-14
• [Presentation] 高齢冠動脈バイパス術後患者における心臓リハビリテーション開始時の運動耐容能, 下肢筋力への糖尿病の影響 (2012)
  • Author(s): 西谷美帆, 島田和典, 砂山聡, 正木克由規, 久米淳美, 深尾宏祐, 蔡栄龍, 吉原琢磨, 大村寛敏, 大西朋 , 塩谷みき , 佐藤裕之 , 山本平, 天野篤 , 代田浩之
  • Organizer: 第18回日本心臓リハビリテーション学会学術総会
  • Place of Presentation: 大宮, 埼玉
  • Year and Date: 2012-07-14
• [Presentation] 冠動脈バイパス術後患者における糖尿病の影響心臓リハビリテーション前後の運動耐容能, 筋力, 筋肉量の比較 (2011)
  • Author(s): 西谷美帆, 島田和典, 砂山聡, 正木克由 規, 久米淳美, 深尾宏祐, 蔡栄龍, 大村寛敏, 大西朋 , 塩谷みき , 佐藤裕之 , 嶋田晶江, 山本平, 天野篤 , 代田浩之
  • Organizer: 日本心臓病学会誌6巻
  • Year and Date: 20110800
• [Presentation] 心臓バイパス術後患者における急性期心臓リハビリテーション開始時の運動耐容能・下肢筋力への糖尿病の影響 (2011)
  • Author(s): 西谷美帆, 島田和典, 砂山聡, 正木克由規, 久米淳美, 深尾宏祐, 蔡栄龍, 山下晴世, 大村寛敏, 大西朋, 塩谷みき , 佐藤裕之, 嶋田晶江, 山本平, 天野篤, 代田浩之
  • Organizer: 日本心臓リハビリテーション学会プログラム・抄録集第17回
  • Year and Date: 20110700
• [Presentation] Predictive values of C-reactive protein and polyunsaturated fatty acids for cardiocerebrovascular events and mortality after elective percutaneous coronary intervention with drug-eluting stents (2011)
  • Author(s): Shimada K, Sai E, Miyauchi K, Masaki Y, Kojima T, Yoshihara T, Ohsaka H, Fukao K, Hirose K, Miyazaki T, Ohsaka A, Daida H
  • Organizer: ISHR
  • Place of Presentation: Tokyo
  • Year and Date: 20110000
• [Presentation] M1, but Not M2 macrophages, characteristically respond to oxidized low-density lipoprotein : Transcriptional analysis in human polarized macrophages (2011)
  • Author(s): Hirose K, Shimada K, Iwabuchi K, Kiyanagi T, Iwahara C, Nakayama H, Yamashita H, Miyazaki T, Kume A, Hiki M, Fukao K, Matsumori R, Ohsaka H, Masuda H, Sai E, Daida H
  • Organizer: Circulation
  • Year and Date: 20110000
• [Presentation] Associations between muscle mass, muscle strength, and exercise tolerance in patients with or without diabetes after coronary artery bypass grafting (2011)
  • Author(s): Nishitani M, Shimada K, Sunayama S, Masaki M, Kume A, Fukao K, Sai E, Yamashita H, Ohmura H, Onishi T, Shioya M, Sato H, Shimada A, Yamamoto T, Amano A, Daida H
  • Organizer: EuroPREVENT 2011
  • Place of Presentation: Geneva. Switzerland
  • Year and Date: 20110000
• [Presentation] Effects of cardiac rehabilitation on muscle mass, muscle strength and exercise tolerance in diabetic patients after coronary artery bypass grafting (2011)
  • Author(s): Nishitani M, Shimada K, Sunayama S, Kume A, Onishi T, Sato H, Amano A, Daida H
  • Organizer: ICCAD 2011
  • Place of Presentation: Venice. Italy
  • Year and Date: 20110000
• [Book] 冠動脈疾患を予防します.そうだったんだ脂肪酸 (2013)
  • Author(s): 島田和典, 高橋修平
  • Total Pages: 98-103
  • Publisher: 文光堂
• [Book] 新たな血管内皮機能評価法Endo-PAT2000の有用性.Diabetes Journal : 糖尿病と代謝 (2013)
  • Author(s): 比企誠, 島田和典, 代田浩之
  • Total Pages: 39-44
• [Book] Macrophages : Life Cycle, Functions and Participation in the Pathogenesis of Atherosclerosis. Handbook of Macrophages : Life Cycle, Functions and Diseases (2012)
  • Author(s): Hirose K, Kiyanagai T, Shimada K, Daida H, Iwabuchi K
  • Total Pages: 423-434
  • Publisher: Nova Science Publishers, Inc
• [Book] Th1/Th2バランス.Heart View循環器のバイオマーカー (2012)
  • Author(s): 島田和典, 高橋修平, 恩田俊仁
  • Total Pages: 192-195
  • Publisher: メジカルビュー社
• [Book] 動脈硬化症.新臨床栄養学第2版 (2012)
  • Author(s): 島田和典
  • Total Pages: 381-387
  • Publisher: 医学書院
• [Book] 各種バイオマーカーの循環器疾患における意義Th1/Th2バランス, Heart View (2012)
  • Author(s): 島田和典, 高橋秀平, 恩田俊仁
  • Total Pages: 192-195
• [Book] 虚血性心疾患の栄養管理心臓リハビリテーションとは, 臨床栄養 (2012)
  • Author(s): 正木克由規, 島田和典, 代田浩之
  • Total Pages: 38-43
• [Book] 動脈硬化関連バイオマーカー最新の知見炎症関連分子, 循環器内科 (2011)
  • Author(s): 吉原琢磨, 島田和典, 代田浩之
  • Total Pages: 177-181
• [Book] 炎症と理学療法慢性炎症と生活習慣病, 理学療法ジャーナル (2011)
  • Author(s): 蔡榮龍, 島田和典, 代田浩之
  • Total Pages: 419-426
• [Book] 心臓リハビリテーション・運動療法のプラ-ク安定化作用と血管保護効果, 呼吸と循環 (2011)
  • Author(s): 西谷美帆, 島田和典, 代田浩之
  • Total Pages: 227-232
• [Book] 動脈硬化と心臓リハビリテーション. 心臓リハビリテーション (2011)
  • Author(s): 島田和典, 深尾宏祐, 大西朋, 西谷美帆, 正木克由規, 井上奈穂, 住吉克彦, 豊田佐織, 高橋康恵, 角 出貴宏, 久米淳美, 山下晴世, 大坂裕通, 蔡榮龍, 家崎貴文, 多田昇弘, 内藤久士, 代田浩之
  • Total Pages: 40-43