2013 Fiscal Year Final Research Report
Development of exercise prescription for the prevention of chronic pain onset associated with hindlimb immobilization
| Project/Area Number |
23500628
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Aichi Medical University |
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Principal Investigator |
OHMICHI MIKA 愛知医科大学, 医学部, 助教 (30581079)
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| Co-Investigator(Kenkyū-buntansha) |
OHMICHI Yusuke 愛知医科大学, 医学部, 助教 (50506673)
OHISHI Hitoshi 愛知医科大学, 医学部, 准教授 (00252461)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 不動化 / 慢性痛 / 自発運動 / 運動療法 / 神経科学 |
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| Research Abstract |
The aim of the present study was the development of an effective therapy of chronic pain. In order to achieve it, we performed a series of experiments to confirm whether the preventive exercise is effective against the chronic pain. We let a group of rats exercise voluntary for 2 weeks using running wheel, while the other group did not do the exercise. Then we made chronic post-cast pain (CPCP) model and performed behavioral and immunohistochemical examination. We found that the chronic mechanical hyperalgesia in rats that exercised before CPCP was induced was more decrease compared with the rats that did not do the pre-exercise. Moreover, as the mechanical hyperalgesia of the tail farthest from the ipsilateral site is reduced, there occurs attenuation of the activation of microglia in the coccygeal cord. Those results suggested the possibility that the exercise performed before the onset of chronic pain may prevent the onset of chronic pain associated with hindlimb immobilization.
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[Journal Article] Treadmill running and static stretching improve long-lasting hyperalgesia, joint limitation, and muscle atrophy induced by cast immobilization in rats2013
Author(s)
Morimoto A, Winaga H, Sakurai H, Ohmichi M, Yoshimoto T, Ohmichi Y, Matsui T, Ushida T, Okada T, Sato J
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Journal Title
Neuroscience letters
Volume: 534
Pages: 295-300
DOI
Peer Reviewed
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[Journal Article] Two-week cast immobilization induced chronic widespread hyperalgesia in rats2012
Author(s)
Ohmichi Y, Sato J, Ohmichi M, Sakurai H, Yoshimoto T, Morimoto A, Hashimoto T, Eguchi K, Nishihara M, Arai YC, Ohishi H, Asamoto K, Ushida T, Nakano T, Kumazawa T
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Journal Title
Eur J Pain
Volume: 16
Pages: 338-348
DOI
Peer Reviewed
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[Journal Article] Frequency components of systolic blood pressure variability reflect vasomotor and cardiac sympathetic functions in conscious rats2011
Author(s)
Yoshimoto T, Eguchi K, Sakurai H, Ohmichi Y, Hashimoto T, Ohmichi M, Morimoto A, Yamaguchi Y, Ushida T, Iwase S, Sugenoya J, Kumazawa T
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Journal Title
The journal of physiological sciences JPS
Volume: 61
Pages: 373-383
DOI
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