Exercise induced expressions of transforming factors in skeletal muscle, fat tissue, vessel walls, and hippocampus.

2014 Fiscal Year Final Research Report

• Project/Area Number: 23500834
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Akita University
• Principal Investigator: OKADA Kyoji 秋田大学, 医学(系)研究科(研究院), 教授 (10185431)
• Co-Investigator(Kenkyū-buntansha): TSUKIYAMA Katsushi 秋田大学, 医学部, 准教授 (10359797) ; OTOMO Kazuo 秋田大学, 大学院医学系研究科, 教授 (30006754)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: メタボリック症候群 / PPAR-gamma / 運動 / レプチン受容体

Outline of Final Research Achievements

Mice with metabolic syndrome were developed by feeding of high caloric diet . The mice were divided into control and exercise group. The exercise　was performed for 12 weeks. Percentage of body fat, tolerance for insulin, oral glucose tolerance test were examined. Percentage of body fat was evaluated by computed tomography and spectrum of near-infrared spectroscopy (NIS). Glucose assay were performed. Immunohistochemical expression of PPAR-g and leptin receptor were evaluated in liver and pancreas. Percentage of body fat and tolerance for insulin were better in the groups with exercise. Expression of PPAR-g in the vessel walls within pancreas, and leptin receptor in the liver increased in the groups with exercise, and these might be related with better outcome of lipid metabolism. Percentage body fat calculated from NIS were strongly correlated with the value measured in CT.

Free Research Field

医学