2013 Fiscal Year Final Research Report
The investigations of the effects of fatty acids administration on the functions of aorta
| Project/Area Number |
23500851
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Josai University |
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Principal Investigator |
KASONO KEIZO 城西大学, 薬学部, 教授 (90177387)
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| Co-Investigator(Kenkyū-buntansha) |
NOBE Kouji 城西大学, 薬学部, 准教授 (30276612)
TAKENOUCHI Yasuhiro 城西大学, 薬学部, 助手 (30582233)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血管内皮機能 / エイコサペンタエン酸 / 血管収縮反応 / 血管弛緩反応 / 脂肪酸 |
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| Research Abstract |
1.Chronic administration of eicosapentaenoic acid ethyl ester (EPA-E) improved Ach-induced relaxation reactivity in the aorta of KKAy diabetic mice. 2.Chronic administration of EPA-E showed no effect on SNP-induced relaxation reactivity in the aorta. 3.Chronic administration of EPA-E showed no effect on the contraction reactivity in the aorta. 4.EPA-E(10microM)did not induce any effect. However, EPA, DPA or DHA(10microM) directly induced remarkable relaxation reaction after the contraction induced by PGF2-alpha.5. In conclusion, EPA-E administration showed the therapeutic effect on the functional disorder of vascular endothelial cells in KKAy diabetic mice.
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[Journal Article] Unsaturated fatty acids in fish oil play a role in adequate fat distribution to plasma, liver and white adipose tissue2011
Author(s)
Sachiko Shiba, Nobuyo Tsunoda, Kanako Ito, Masaki Wakutsu, Etsuko Muraki, Mariko Sonoda, Phyllis. S. Y. Tam, Yoko Fujiwara, Shinji Ikemoto, Keizo Kasono
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Journal Title
J. Health Sci
Volume: 57(4)
Pages: 341-349
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