2013 Fiscal Year Final Research Report

Investigation of the onset and progression of cognitive dysfunction in young diabetics

Research Project

Project/Area Number	23500858
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Applied health science
Research Institution	Juntendo University
Principal Investigator	OHMURA Chie 順天堂大学, 医学部, 准教授 (30459135)
Co-Investigator(Kenkyū-buntansha)	SHIMIZU Tomoaki 順天堂大学, 医学部, 准教授 (30384077)
Project Period (FY)	2011 – 2013
Keywords	糖尿病 / 軽度認知機能障害 / 臭覚テスト
Research Abstract	Cognitive impairment can potentially affect diabetes self-care and adherence to medication, with consequent deterioration of glycemic control. In terms of management of T2DM, it is crucial to prevent the development of cognitive impairment at an early stage or halt its progression. In this regard, it is important to identify makers for early cognitive impairment in patients with T2DM. Recent studies have shown that olfactory dysfunction could be used as a predictor of cognitive impairment in the general population. The aim of the present study was to define the relation between olfactory function and cognition in elderly patients with type 2 diabetes mellitus.Among patients with T2DM aged more than 65 years with free of clinically-evident cognitive impairment,MCI was diagnosed in 24.4%, and dementia in 13.6%.Stepwise multivariate regression analysis identified OE test score, education level, HbA1c, and serum adiponectin as independent factors associated with MMSE score