2013 Fiscal Year Final Research Report
Influence of maternal intake of n-3 fatty acid on fatty acid transport of fetal blood brain barrier
| Project/Area Number |
23500956
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TOKUDA NOBUKO 山口大学, 医学(系)研究科(研究院), 教授 (70227578)
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| Co-Investigator(Kenkyū-buntansha) |
OWADA Yuji 山口大学, 大学院・医学系研究科, 教授 (20292211)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脂肪酸 / 胎盤 / 血管 / 血液脳関門 / 情動行動 / 脳 / 神経 / オリゴデンドロサイト |
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| Research Abstract |
Epidemiological studies suggest that maternal dietary poor intake of n-3 and some fatty acids may trigger certain mental disorders of fetus. However, the molecular basis of their actions is still unknown. Our findings show that fatty acid binding protein 3 (FABP3) controls fatty acid trafficking in mouse placenta and the transport is important for fetal development. FABP3 also regulates cognitive function and anxiety behaviors. In mouse brain, FABP5 and FABP7 are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation.
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Research Products
(44 results)
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[Journal Article] The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse2012
Author(s)
Matsumata, M., Sakayori, N., Maekawa, M., Owada, Y., Yoshikawa, T. and Osumi, N.
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Journal Title
Stem Cells
Volume: 30
Pages: 1532-43
DOI
Peer Reviewed
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