2013 Fiscal Year Final Research Report
molecular mechanisms of Ink4a/Arf locus that cofers cell aging and differentiation
| Project/Area Number |
23501277
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NAKADE koji 独立行政法人理化学研究所, バイオリソースセンター, 協力研究員 (20392053)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 細胞分化 / iPS / 心筋細胞 / アデノウイルスベクター / エピジェネティックス / ヒストン / クロマチン / メチル化 |
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| Research Abstract |
We have analyzed molecular mechanisms of JDP2 in the epigenetic regulation of Ink4a locus and found that JDP2 helps maintaining non-methylation status of histones by concerting with histone demethylase, Jmjd3, not only by inhibiting the activity of methytransferases, PRC1 and PRC2. In addition, in order to analyze the effect of JDP2 on differentiation and de-differentiation, we established, as a model, adenoviral gene introduction system that successfully induced cardiomyocyte and iPS from mouse embryo fibroblast. Using these system, we obtained the result that the inducibility of diffrentiation and de-diffrentiation was improved in the absence of JDP2.
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[Journal Article] Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters2013
Author(s)
Hasegawa N, Abei M, Yokoyama KK, Fukuda K, Seo E, Kawashima R, Nakano Y, Yamada T, Nakade K, Hamada H, Obata Y, Hyodo I
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Journal Title
Int J Cancer
Volume: 133(6)
Pages: 1479-1488
DOI
Peer Reviewed
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[Journal Article]2012
Author(s)
Inagawa K, Miyamoto K, Yamakawa H, Muraoka N, Sadahiro T, Umei T, Wada R, Katsumata Y, Kaneda R, Nakade K, Kurihara C, Obata Y, Miyake K, Fukuda K, Ieda M
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Journal Title
Circ Res
Volume: 111(9)
Pages: 1147-1156
DOI
Peer Reviewed
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