2013 Fiscal Year Final Research Report
Basic research for the development of multi-peptide cocktail vaccines for cancer
| Project/Area Number |
23501292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Kurume University |
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Principal Investigator |
YAMADA Akira 久留米大学, 先端癌治療研究センター, 教授 (50158177)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ワクチン療法 |
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| Research Abstract |
Personalized peptide vaccine therapy must overcome several hurdles before being used as a general treatment for cancer. To this end, non-personalized multi-peptide cocktail vaccines that exhibit similar clinical effects without requiring time-consuming laboratory tests will be needed. In the present study, we have developed two new cocktail vaccines consisting of 20 peptides (KRM-20) and 10 peptides (KRM-10) for the treatment of prostate cancer and gastrointestinal cancers, respectively, by selecting the reactivity levels of their plasma IgG antibodies and cytotoxic T-lymphocyte-inducing activities. In addition, immunological analyses of blood samples of clinical trials suggested the immunological minimum effective doses.
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Research Products
(51 results)
