2013 Fiscal Year Final Research Report
Effect of environmental chemicals on brain development ; examination of the various aspects in glias and neurons.
| Project/Area Number |
23510072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Gunma University |
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Principal Investigator |
IWASAKI TOSHIHARU 群馬大学, 医学(系)研究科(研究院), 講師 (80375576)
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| Co-Investigator(Kenkyū-buntansha) |
KOIBUCHI Noriyuki 群馬大学, 大学院医学系研究科, 教授 (80234681)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 甲状腺ホルモン / 脳発達 / アストロサイト / 環境化学物質 / 神経成長因子 |
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| Research Abstract |
We showed that PBDE, BP-6, HBCD and PFOS impaired TH-mediated Purkinje cell dendrite arborization using primary culture of rat cerebellar cells. On the other hand, 4-NP increased the dendrite arborization. PBDE, BP-6 and HBCD inpaired TH-mediated granule cell neurite development, while 4-NP incresed. PBDE, BP-6 and HBCD suppressed the TR-mediated transcription due to dissociation of TR-TRE binding. PFOS may suppressed the dendrite arborization though a novel pathway such as effects of astrocyte function. 4-NP may recruit the cofactors to TR. Lipopolysacchalide (LPS) suppressed the actin polymerization and D2 activity through p38 MAP kinase pathway. We analyzed mice expressing a dominant-negative TRbeta1 (G345R) specifically in the cerebellar Purkinje cells. Homo mice showed aberrant cerebellar development. We investigated functions of a newly cloned corepressor, brain-derived repressive molecule (B-ReM).
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[Journal Article] Altered cerebellum development and dopamine distribution in a rat genetic model with congenital hypothyroidism2014
Author(s)
Shimokawa N, Yousefi B, Morioka S, Yamaguchi S, Ohsawa A, Hayashi H, Azuma A, Mizuno H, Kasagi M, Masuda H, Jingu H, Furudate SI, Haijima A, Takatsuru Y, Iwasaki T, Umezu M, Koibuchi N
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Journal Title
J Neuroendocrinol
Volume: 26
Pages: 164-175
DOI
Peer Reviewed
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[Journal Article] Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines2014
Author(s)
Yamazaki H, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T
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Journal Title
J Neurochem
Volume: 128
Pages: 507-522
DOI
Peer Reviewed
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[Journal Article] Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder2014
Author(s)
Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara H, Shimoyama D, Takatsuru Y, Iwasaki T, Shimokawa N, Takagishi K, Koibuchi N
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Journal Title
Physiological Rep
Volume: 2
Pages: e00197
DOI
Peer Reviewed
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[Journal Article] Effects of perinatal lipopolysaccharide (LPS) exposure on the developing rat brain ; modeling the effect of maternal infection on the developing human CNS2013
Author(s)
Xu M, Sulkowski ZL, Parekh P, Khan A, Chen T, Midha S, Iwasaki T, Shimokawa N, Koibuchi N, Zavacki AM, Sajdel-Sulkowska EM
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Journal Title
Cerebellum
Volume: 12
Pages: 572-586
DOI
Peer Reviewed
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[Journal Article] Alterations of biochemical marker levels and myonuclear numbers in rat skeletal muscle after ischemia-reperfusion2013
Author(s)
Itoh M, Shimokawa N, Tajika Y, Murakami T, Aotsuka N, Lesmana R, Farenia R, Iwasaki T, Okada J, Yorifuji H, Koibuchi N
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Journal Title
Mol Cell Biochem
Volume: 373
Pages: 11-18
DOI
Peer Reviewed
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[Presentation] Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat2011
Author(s)
Yamaguchi S, Ohsawa A, Yousefi B, Morioka S, Masuda H, Ronny, Hayashi H, Takatsuru Y, Iwasaki T, Shimokawa N, Umezu M, Koibuchi N
Organizer
4th International Symposium of the Society for Research on the Cerebellum
Place of Presentation
Tokyo
Year and Date
2011-09-18
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