2013 Fiscal Year Final Research Report
UVA activated N-nitrosoproline induced damages on DNA, protein and membrane, and disturbance of signal transduction
| Project/Area Number |
23510075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Okayama University |
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Principal Investigator |
ARIMOTO Sakae 岡山大学, 医歯(薬)学総合研究科, 准教授 (90212654)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ニトロソプロリン / UVA / DNA損傷 / 一酸化窒素 / アルキルラジカル / DNA付加体 / 遺伝毒性 / 小核形成 |
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| Research Abstract |
We investigated near-ultraviolet radiation (UVA) mediated chemical reaction of N-nitrosoproline (NPRO) with DNA, deoxynucleosides, amino acids and membrane lipids, and isolated several new products from the UVA-irradiated mixture. Photogenotoxicity was found with NPRO towards human derived keratinocyte cells. Nitric oxide was released during photoreaction of NPRO to create active radicals that can give phototoxicity.
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Research Products
(11 results)
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[Journal Article] Mutagenicity and NO formation from UVA irradiated N-nitrosoproline, and characterization of photoproduct formed in UVA-irradiated mixture of N-nitrosoproline with 2'-deoxyguanosine in neutral solution2014
Author(s)
Arimoto-Kobayashi, S., Machida, M., Sano, K., Aoyama, S., Asahi, C., Tanaka, N., Okamoto, K., Negishi, T., Kimura, S. and Suzuki, T
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Journal Title
Genes and Environment
Volume: Vol. 36(2)
DOI
Peer Reviewed
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[Journal Article] Near ultraviolet radiation-mediated reaction between N-nitrosoproline and DNA : Isolation and identification of two new adducts, (R)-and (S)-8-(2-pyrrolidyl)-2'-deoxyguanosine2013
Author(s)
Aoyama, S., Sano, K., Asahi, C., Masaki Machida, Okamoto, K., Negishi, T., Kimura, S., Suzuki, T., Hatano, T. and Arimoto-Kobayashi, S
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Journal Title
Journal of Photochemistry and Photobiology A : Chemistry
Volume: Vol. 276
Pages: 1-7
DOI
Peer Reviewed
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[Presentation] Near ultraviolet light-mediated reaction between N-nitrosoproline and DNA : Isolation and identification of new adducts2013
Author(s)
Arimoto-Kobayashi, S., Aoyama, S., Asahi, C., Sano, K., Machida, M., Okamoto, K., Negishi, T., Kimura, S., Suzuki, T. and Hatano, T
Organizer
The 6th Asia and Oceania Conference on Photobiology
Place of Presentation
シドニー
Year and Date
20131110-13
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