2013 Fiscal Year Final Research Report
Quantitative analysis of neonatal exposure to thyroid hormone disrupting chemicals
| Project/Area Number |
23510076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
FUJIMOTO Nariaki 広島大学, 原爆放射線医科学研究所, 准教授 (40243612)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Shigeyuki 日本薬科大学, 薬学部, 教授 (40136057)
SANOH Seigo 広島大学, 医歯薬保健学研究科, 助教 (00552267)
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| Project Period (FY) |
2011-04-28 – 2014-03-31
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| Keywords | 内分泌かく乱物質 / 下垂体甲状腺系 / 肝臓 / 甲状腺ホルモン / 臭素化難燃剤 |
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| Research Abstract |
There have been many concerns regarding the possible adverse effects of thyroid hormone-disrupting chemicals such as PBDEs. Our results suggested that thyroid hormone-disrupting actions (agonism of antagonism) of PBDEs differ among target tissues or species. Our in vivo studies demonstrated that neonatal exposure to T3 altered the expression of some hepatic genes, including TRa2 and Ugt1A1 in the adult stage, suggesting that neonatal exposure to thyroid hormone-disrupting chemicals may affect the gene expression profile of the thyroid axis in adulthood.
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[Journal Article] In vitro metabolism of cis-and trans-permethrin by rat liver microsomes, and its effect on estrogenic and anti-androgenic activities2014
Author(s)
Tange, S., Fujimoto, N., Uramaru, N., Sugihara, K., Ohta, S., Kitamura, S
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Journal Title
Environ. Toxicol. Pharmacol
Volume: 37
Pages: 996-1005
DOI
Peer Reviewed
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[Journal Article] Cell type-dependent agonist/antagonist activities of polybrominated diphenyl ethers2013
Author(s)
Nakamura, N., Matsubara, K., Sanoh, S., Ohta, S., Uramaru, N., Kitamura, S., Yamaguchi, M., Sugihara, K., Fujimoto, N
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Journal Title
Toxicol. Lett
Volume: 223
Pages: 192-197
DOI
Peer Reviewed
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[Journal Article] Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats2012
Author(s)
Fujimoto., N., Inoue, K., Yoshida, M., Nishikawa, A., Ozawa, S., Gamou, T., Nemoto, K., Degawa, M
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Journal Title
J. Toxicol. Sci
Volume: 37
Pages: 281-286
URL
Peer Reviewed
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[Journal Article] An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide2012
Author(s)
Matsubara, K., Sanoh, S., Ohta, S., Kitamura, S., Sugihara, K., Fujimoto, N
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Journal Title
Toxicol. Lett
Volume: 208
Pages: 30-35
DOI
Peer Reviewed
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[Presentation] 甲状腺ホルモン様化学物質アミオダロン曝露によるカエルの変態に対する影響2012
Author(s)
佐能正剛, 柏木啓子, 花田秀樹, 松原加奈, 川畑公平, 中村直樹, 鈴木賢一,山本卓, 新海 正, 藤本成明, 杉原数美, 北村繁幸, 柏木昭彦, 太田茂
Organizer
環境ホルモン学会第15回研究発表会
Place of Presentation
東京
Year and Date
2012-12-18
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[Presentation] Effects of neonatal exposure to thyroid hormones on gene expression profile of the pituitary-thyroid-liver in rats2012
Author(s)
Fujimoto, N., Matsubara, K., Sanoh, S., Ohta, S., Kitamura, S., Sugihara, K
Place of Presentation
フェレンツェ(イタリア)
Year and Date
2012-05-08
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[Presentation] 甲状腺ホルモン様物質のアフリカツメガエルの自然変態に対する影響評価2011
Author(s)
佐能正剛, 柏木啓子, 花田秀樹, 松原加奈,川畑公平, 新海正, 山本卓, 鈴木賢一, 藤本成明, 杉原数美,北村繁幸, 柏木昭彦, 太田茂
Organizer
環境ホルモン学会第14回研究発表会
Place of Presentation
東京
Year and Date
2011-12-01
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