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2015 Fiscal Year Final Research Report

Search of naturally-occurring anti-cancer agent targeted to a practical biological molecules derived from clinical cancer cells.

Research Project

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Project/Area Number 23510284
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical biology
Research InstitutionHyogo University of Health Sciences

Principal Investigator

AOKI SHUNJI  兵庫医療大学, 薬学部, 教授 (60252699)

Co-Investigator(Renkei-kenkyūsha) TSUJIKAWA KAZUTAKE  大阪大学, 大学院薬学研究科, 教授 (10207376)
Project Period (FY) 2011-04-28 – 2016-03-31
KeywordsPCA-1 / DNA, RNA脱メチル化酵素 / 前立腺がん / 膵臓がん / 分子標的抗がん剤 / アポトーシス
Outline of Final Research Achievements

A DNA and/or RNA-alkylating damage-repair enzyme called prostate cancer antigen (PCA)-1 is highly expressed in clinical androgen-independent prostate cancer cells and pancreatic cancer cells. Genetic inhibition of the enzymatic activity by injecting siRNA effectively inhibited the growth of prostate and pancreatic cancer cells. Therefore, PCA-1 inhibitor would be a novel and clinically effective anti-cancer drug against prostate cancer, even for hormone independent varieties and pancreatic cancer.
On the other hand, on the guidance of inhibition against PCA-1 enzymatic activity, we tried to search for anti-cancer substances from extracts of medicinal plants. We found several active extract and isolate the active components by the assay-guided separation.

Free Research Field

天然薬物学

URL: 

Published: 2017-05-10  

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