Search of naturally-occurring anti-cancer agent targeted to a practical biological molecules derived from clinical cancer cells.

2015 Fiscal Year Final Research Report

• Project/Area Number: 23510284
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: Hyogo University of Health Sciences
• Principal Investigator: AOKI SHUNJI 兵庫医療大学, 薬学部, 教授 (60252699)
• Co-Investigator(Renkei-kenkyūsha): TSUJIKAWA KAZUTAKE 大阪大学, 大学院薬学研究科, 教授 (10207376)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Keywords: PCA-1 / DNA, RNA脱メチル化酵素 / 前立腺がん / 膵臓がん / 分子標的抗がん剤 / アポトーシス

Outline of Final Research Achievements

A DNA and/or RNA-alkylating damage-repair enzyme called prostate cancer antigen (PCA)-1 is highly expressed in clinical androgen-independent prostate cancer cells and pancreatic cancer cells. Genetic inhibition of the enzymatic activity by injecting siRNA effectively inhibited the growth of prostate and pancreatic cancer cells. Therefore, PCA-1 inhibitor would be a novel and clinically effective anti-cancer drug against prostate cancer, even for hormone independent varieties and pancreatic cancer.
On the other hand, on the guidance of inhibition against PCA-1 enzymatic activity, we tried to search for anti-cancer substances from extracts of medicinal plants. We found several active extract and isolate the active components by the assay-guided separation.

Free Research Field

天然薬物学