2013 Fiscal Year Final Research Report
Simulated pathology of influenza A/H5N1
| Project/Area Number |
23540156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General mathematics (including Probability theory/Statistical mathematics)
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| Research Institution | Josai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Kazuo 帝京大学, 医学部, 教授 (20192130)
KAWACHI Shoji 国立国際医療研究センター, 手術部, 部長 (60152972)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 新型インフルエンザ / 数理モデル / シミュレーション / 白血球減少症 / 急性呼吸促迫症候群 |
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| Research Abstract |
Background: Fulminant acute respiratory distress syndrome (ARDS) is a major symptom of infection with influenza A/H5N1virus. Patients with influenza A/H5N1 suffer from leukopenia. Nevertheless, the association of cellular injury with leukopenia remains unclear.
Methods and findings: A within-host mathematical model, a system of delay differential equations of virus dynamics and immune response, was applied to ascertain influenza pathogenesis. When leukocytes destroy infected cells, the ratio of leukocyte destruction becomes higher in the case of A/H5N1. Moreover, a comparison of therapies for leukopenia using the model reveals that immunoglobulin therapy is more effective than neuraminidase therapy.
Conclusion: Simulations show that the increased ratio of destruction of leukocytes induces leukopenia and cellular injury of A/H5N1. Furthermore, results of simulations demonstrate the possibility of immunoglobulin therapy for treating leukopenia associated with influenza A/H5N1.
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