Multicolor saccharide-sensing chips based on boronic acid-containing thin films

2013 Fiscal Year Final Research Report

• Project/Area Number: 23550088
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: Kitami Institute of Technology
• Principal Investigator: KANEKIYO Yasumasa 北見工業大学, 工学部, 准教授 (40435748)
• Co-Investigator(Kenkyū-buntansha): AOKI Hiroshi 独立行政法人産業技術総合研究所, 主任研究員 (00392580)
• Co-Investigator(Renkei-kenkyūsha): KUBO Shiori 独立行政法人産業技術総合研究所, 主任研究員 (20435770)
• Project Period (FY): 2011 – 2013
• Keywords: ボロン酸 / 糖センサー / 薄膜 / 色素 / フルクトース / グルコース / 交互吸着 / 交互積層

Research Abstract

Novel saccharide-sensing chips that show distinct color changes were developed. The saccharide-responsive thin films were obtained on a pattern-printed microscope slide via a layer-by-layer method utilizing a boronic acid-containing polycation. After adsorption of anionic dyes, the thin films were immersed in aqueous saccharide solutions. As the saccharide concentration increased, the thin films showed a multi-patterned color change that enabled the quantification of saccharides using multi-colorimetric sensing.

Research Products

• [Journal Article] Multicolor saccharide-sensing chips created via layer-by-layer adsorption of boronic acid-containing polymers (2014)
  • Author(s): W. Takayoshi, M. Imajo, M. Iijima, M. Suzuki, H. Yamamoto, Y. Kanekiyo
  • Journal Title: Sensor. Actuat. B-Chem Volume: 192 Pages: 776-781
  • DOI: 10.1016/j.snb.2013.11.008
  • Peer Reviewed
• [Journal Article] Multicolor sensor arrays for saccharide analysis based on boronic acid-containing thin films combined with various anionic dyes (2013)
  • Author(s): Y. Iwami, H. Yamamoto, Y. Kanekiyo
  • Journal Title: Chem. Lett Volume: 42 Pages: 1214-1216
  • DOI: 10.1246/cl.130599
  • Peer Reviewed
• [Journal Article] Multicolor saccharide-sensing chips based on boronic acid-containing thin films showing stepwise release and binding of dyes (2011)
  • Author(s): Y. Iwami, T. Yokozawa, W. Takayoshi, Y. Kanekiyo
  • Journal Title: Talanta Volume: 85 Pages: 829-833
  • DOI: 10.1016/j.talanta.2011.04.068
  • Peer Reviewed
• [Presentation] 新規ボロン酸構造の導入による色調変化型糖センサーの高感度化 (2014)
  • Author(s): 山本浩樹, 兼清泰正
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2014-03-29
• [Presentation] Effect of boronic acid structure on the responsiveness of saccharide-sensing chips (2013)
  • Author(s): H. Yamamoto, C. Konishi, Y. Kanekiyo
  • Organizer: ASIANALYSIS XII
  • Place of Presentation: 九州大学
  • Year and Date: 2013-08-22
• [Presentation] 糖応答性薄膜の変色挙動に及ぼすボロン酸構造の影響 (2013)
  • Author(s): 山本浩樹, 兼清泰正
  • Organizer: 第73回分析化学討論会
  • Place of Presentation: 北海道大学
  • Year and Date: 2013-05-18
• [Presentation] 糖尿病予防・管理に向けたパーソナルユース糖センサー (2013)
  • Author(s): 兼清泰正
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学
  • Year and Date: 2013-03-23
• [Presentation] A Multicolor saccharide sensing chip created by layer-by-layer adsorption of a boronic acid-containing polymer (2012)
  • Author(s): Y. Kanekiyo, W. Takayoshi, M. Iijima
  • Organizer: SISYS2012
  • Place of Presentation: 産業技術総合研究所(つくば)
  • Year and Date: 2012-11-21
• [Presentation] ボロン酸含有交互吸着膜を用いた糖センサーが示す迅速かつ明瞭多彩な色調変化 (2012)
  • Author(s): 兼清泰正, 高吉若菜, 鈴木茉莉奈, 飯島瑞貴
  • Organizer: 日本分析化学会第61年会
  • Place of Presentation: 金沢大学
  • Year and Date: 2012-09-21
• [Presentation] A multicolor saccharide sensing chip created by layer-by-layer adsorption of a boronic acid-containing polymer (2012)
  • Author(s): Y. Kanekiyo, W. Takayoshi
  • Organizer: Eurosensors2012
  • Place of Presentation: クラクフ(ポーランド)
  • Year and Date: 2012-09-10
• [Presentation] 交互吸着法により作製した糖応答性薄膜が示す迅速かつ明瞭多彩な色調変化 (2012)
  • Author(s): 高吉若菜, 鈴木茉莉奈, 今庄満幸, 兼清泰正
  • Organizer: 第61回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2012-05-30
• [Presentation] 交互吸着法による糖応答性薄膜の作製と色調変化挙動の解析 (2012)
  • Author(s): 鈴木茉莉奈, 高吉若菜, 兼清泰正
  • Organizer: 第9回ホスト・ゲスト化学シンポジウム
  • Place of Presentation: 北海道大学
  • Year and Date: 2012-05-26
• [Presentation] ボロン酸含有ポリマーを用いたマルチカラー糖センサーアレイの構築 (2011)
  • Author(s): 兼清泰正, 岩見雄人
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-29
• [Presentation] ボロン酸含有薄膜を用いたマルチカラー糖センサーアレイの構築 (2011)
  • Author(s): 兼清泰正, 岩見雄人, 木村聖弥
  • Organizer: 日本分析化学会第60年会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2011-09-14
• [Presentation] ボロン酸含有交互吸着膜を用いた多色変化型糖センシングチップの作製と応答特性の解析 (2011)
  • Author(s): 高吉若菜, 鈴木茉莉奈, 今庄満幸, 兼清泰正
  • Organizer: 日本分析化学会第60年会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2011-09-14
• [Presentation] A multicolor saccharide sensor array based on boronic acid-containing thin films stained with anionic dyes (2011)
  • Author(s): Y. Kanekiyo, Y. Iwami
  • Organizer: ISACS6
  • Place of Presentation: 北京大学
  • Year and Date: 2011-09-03
• [Book] エヌ・ティー・エス, パーソナル・ヘルスケア-ユビキタス, ウェアラブル医療実現に向けたエレクトロニクス最前線- (2013)
  • Author(s): 兼清泰正, 他
  • Total Pages: 245-252
• [Book] Sustainable Carbon Materials from Hydrothermal Processes (2013)
  • Author(s): R. J. White, T.-P. Fellinger, S. Kubo, N. Brun, M.-M. Titirici, Wiley
  • Total Pages: 37-100
• [Remarks] 新聞報道 : "糖の濃度変化, 色で検出", 日経産業新聞, 2012年8月2日, p.11