2013 Fiscal Year Final Research Report
Functional molecules characteristic of the ultimobranchial gland and parathyroid gland
| Project/Area Number |
23570075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Shizuoka University |
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Principal Investigator |
MASAKAZU Suzuki 静岡大学, 理学(系)研究科(研究院), 准教授 (60280913)
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| Co-Investigator(Renkei-kenkyūsha) |
NARUSE Kiyoshi 基礎生物学研究所, バイオリソース研究室, 准教授 (50208089)
KAMEI Yasuhiro 基礎生物学研究所, 生物機能解析センター, 准教授 (70372563)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 鰓後腺 / 副甲状腺 |
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| Research Abstract |
Ultimobranchial gland: Medaka (Oryzias latipes) mutants were generated by targeting induced lesions in genomes (Tilling), and 3 mutants were selected to analyze the function of clusterin. Background mutations were removed by backcrossing with d-rR WT medaka. Currently, F6 hetero-mutants are reared with F6 incrossed homo-mutants, providing a basis for the detailed phenotype analysis.
Parathyroid gland: By cDNA cloning, calcium-sensing receptor and GCM transcription factor were identified in the bullfrog parathyroid gland. Although novel PT1 cDNA was found to be expressed in the parathyroid gland, it had no coding region.
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