2013 Fiscal Year Final Research Report
Age-related changes in ghrelin function, ghrelin concentration and ghrelin related molecules expression in the growing chickens.
| Project/Area Number |
23570081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Rakuno Gakuen University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAIYA Hiroyuki 独立法人国立循環器病研究センター, 研究所, 室長 (40300975)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAI Takafumi 埼玉大学, 理工学研究科, 教授 (40235114)
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| Project Period (FY) |
2011 – 2013
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| Keywords | グレリン / モチリン / 受容体 / グレリン合成酵素 / ニワトリ消化管 / 遺伝子発現調整機構 / 収縮機能 |
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| Research Abstract |
Ghrelin contracted a chicken gastrointestinal tract. The ghrelin-induced contraction and expression of growth hormone secretagogue receptor (GHS-R1a) mRNA in the proventriculus decreased depending on age. Ghrelin concentrations in the proventriculus and plasma increased after hatching and reached plateau at 30 days. Expression of ghrelin and ghrelin-O-acetyltransferase (GOAT) mRNAs also tended to decrease depending on age. Expression of ghrelin mRNA did not show any correlation with plasma ghrelin. Inverse relationships between ghrelin concentration and GHS-R1a and GOAT mRNAs expression are indicative for a ghrelin-induced downregulation of the ghrelin receptor and synthetic enzyme. The expression pattern of ghrelin, GOAT and GHS-R1a mRNAs in the brain distinctly change in region-dependent manner on growing stage. The present results indicated that physiological role of ghrelin system changes in the brain and gastrointestinal tract of growing chickens.
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