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2013 Fiscal Year Final Research Report

Structural analysis of the regulation of mitotic spindle orientation by the cell polarity protein LGN

Research Project

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Project/Area Number 23570141
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural biochemistry
Research InstitutionKyushu University

Principal Investigator

YUZAWA Satoru  九州大学, 医学(系)研究科(研究院), 助教 (40515029)

Project Period (FY) 2011 – 2013
Keywords細胞極性 / 細胞内シグナル伝達 / X線結晶構造解析
Research Abstract

Asymmetric cell division generates cell type diversity and is crucial for the development and tissue organization. The interactions between the cell polarity protein mInsc and LGN regulate mitotic spindle orientation during asymmetric cell division in certain types of cells. The complex of mInsc and LGN is targeted to plasma membrane and form complexes with other proteins. In this project, we have determined the crystal structure of LGN in complex with mInsc and elucidate the molecular mechanism of LGN regulated by its intramolecular interaction.

  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Ubiquitination of the heterotrimeric G protein α subunits Gα i2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A2013

    • Author(s)
      Kanako Chishiki, Sachiko Kamakura, Satoru Yuzawa, Junya Hayase, Hideki Sumimoto.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 435 Pages: 414-419

    • Peer Reviewed
  • [Journal Article] 細胞極性タンパク質LGN とパートナー分子mInsc 複合体の認識機構2012

    • Author(s)
      湯澤 聡
    • Journal Title

      日本結晶学会誌

      Volume: 54 Pages: 206-212

    • Peer Reviewed
  • [Journal Article] Crystal structure of the C-terminal globular domain of oligosaccharyltransferase from Archaeoglobus fulgidus at 1.75 Å resolution2012

    • Author(s)
      Shunsuke Matsumoto, Mayumi Igura, James Nyirenda, Masaki Matsumoto, Satoru Yuzawa, Nobuo Noda, Fuyuhiko Inagaki, Daisuke Kohda.
    • Journal Title

      Biochemistry

      Volume: 51 Pages: 4157-4166

    • Peer Reviewed
  • [Journal Article] Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)2011

    • Author(s)
      Satoru Yuzawa, Sachiko Kamakura, Yuko Iwakiri, Junya Hayase, Hideki Sumimoto.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 108 Pages: 19210-19215

    • Peer Reviewed
  • [Presentation] 細胞極性タンパク質LGN のTPR ドメインによるパートナー分子の多様な認識2012

    • Author(s)
      湯澤聡,鎌倉幸子,岩切優子,早瀬純也,住本英樹
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      20121214-16
  • [Presentation] 細胞極性関連タンパク質 Inscuteable とLGN との複合体のX 線結晶構造解析2011

    • Author(s)
      湯澤聡,鎌倉幸子,岩切優子,早瀬純也,住本英樹
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14

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Published: 2015-07-16  

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