2013 Fiscal Year Final Research Report
Mechanism of the development of local organizers in the brain primordium using zebrafish as a model system
| Project/Area Number |
23570247
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Saitama University |
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Principal Investigator |
YAMASU Kyo 埼玉大学, 大学院理工学研究科, 教授 (60230439)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Akinori 埼玉大学, 大学院理工学研究科, 講師 (10466691)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳形成 / 脳部域化 / 遺伝子制御ネットワーク / ゼブラフィッシュ / 発生遺伝学 / 局所オーガナイザー / 転写制御機構 / 神経分化 |
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| Research Abstract |
We studied the regulatory mechanism of vertebrate brain formation in zebrafish. We revealed the details of the function of two isthmus-forming genes, gbx2 and pou2, suggesting that both are involved in neurogenesis. We also extended the analysis on the transcriptional regulation of an ANB-forming gene, emx3, and two isthmus-forming genes, pax2a and pou2. Meanwhile, it was shown that the development of the neural crest and somite is affected in a novel mutation, kanazutsi, and its causative gene encodes a globin-family protein. In addition, we succeeded in introducing two novel experimental techniques, the GAL4/UAS system and TALEN.
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[Journal Article] Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages2012
Author(s)
A Khan, A Nakamoto, S Okamoto, M Tai, Y Nakayama, K Kobayashi, A Kawamura, H Takeda, K Yamasu
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Journal Title
Mech Dev
Volume: 129
Pages: 219-235
DOI
Peer Reviewed
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