2014 Fiscal Year Final Research Report
Analysis of vertebral column segmentation by the floor plate in medaka
| Project/Area Number |
23570251
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
INOHAYA Keiji 東京工業大学, 生命理工学研究科, 助教 (70302958)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 発生・分化 / メダカ / 骨形成 / 脊椎発生 / 分節性 / Wnt |
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| Outline of Final Research Achievements |
The fu-2 is a spontaneous and recessive medaka mutant, which exhibits fused centra and the absence of the intervertebral ligaments. As a result of positional cloning analysis, the fu-2 locus was mapped to chromosome23, but it was not identified in the medaka ensemble database. This result indicates that the fu-2 locus is locating on unknown region of choromosomal end. Finally, two candidate genes for the fu-2 phenotype, which relate to the Wnt signaling pathway, were found in this unknown region.
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| Free Research Field |
発生生物学
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