Molecular Mechanisms of gene regulatory network during corticogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 23570264
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: OHTAKA-MARUYAMA Chiaki 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 主席研究員 (00281626)
• Co-Investigator(Kenkyū-buntansha): OKADO Haruo 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 副参事研究員 (60221842)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 大脳皮質 / RP58 / 転写制御 / 放射状移動 / 多極性細胞 / 双極性細胞 / Ngn2 / Rnd2

Outline of Final Research Achievements

Expansion of human cortex during evolution depends in large part in developmental program that enables elaboration of neural circuit. During the formation of 6-layered neocortical structure, newborn neurons depart the ventricular zone and migrate toward the pial surface. It is suggested that impairment of these steps leads to develop brain malformation or various mental disorders. However, detailed molecular mechanisms are remained to be elucidated. In this study, we identified RP58 transcriptional repressor as a novel regulator for radial neuronal migration and revealed that negative feedback regulation of transcriptional regulatory network including RP58 and Ngn2 was critical for this regulation.

Free Research Field

神経発生学