2013 Fiscal Year Final Research Report
Characterization of antenna-specific cholesterol-binding protein in the ant
| Project/Area Number |
23580070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied entomology
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| Research Institution | Toyama Prefectural University (2012-2013)
Kobe University (2011) |
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Principal Investigator |
ISHIDA Yuko 富山県立大学, その他部局等, 研究員 (90509861)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Toshimasa 独立法人農業生物資源研究所, 農業生物先端ゲノム研究センター, ユニット長 (40360458)
MIYAZAWA Mitsuhiro 独立法人農業生物資源研究所, 農業生物先端ゲノム研究センター, ユニット長 (90370684)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIBASHI Jun 独立法人農業生物資源研究所, 農業生物先端ゲノム研究センター, 主任研究員 (20391576)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ニーマンピック2型タンパク質 / クロオオアリワーカー / 蛍光拮抗アッセイ / 円偏光二色性 / GC-EAD / 結晶化学 / 情報伝達物質 |
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| Research Abstract |
We identified Niemann-Pick type C2 protein antenna-specifically expressed in worker of the Japanese carpenter ant, Camponotus japonicus. In human, this protein plays an essential role in transferring cholesterol in the cells whereas ant accumulated this protein in the basiconic sensillum and used it as a carrier protein for semiochemicals such as long-chain fatty acids, alcohols, and acetates. The protein was composed of beta-structure. The molecular mechanism of binding release was regulated by hydrogen network formation and angle change of side chain of the 112th tryptophan residue.
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Research Products
(16 results)
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[Journal Article] Niemann-Pick type C2 protein mediating chemical communication in the worker ant2014
Author(s)
Ishida, Y., Tsuchiya, W., Fujii, T., Fujimoto, Z., Miyazawa, M., Ishibashi, J., Matsuyama, S., Ishikawa, Y., and Yamazaki, T
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 111
Pages: 3847-3852
DOI
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[Remarks] 共同通信PRワイヤー、CNET Japan、産経新聞、中日新聞、農業協同組合新聞、日本農業新聞、化学工業日報、北日本新聞、富山新聞など様々なメディアで本研究成果(雑誌論文1)が紹介された。
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[Remarks] 講演, クロオオアリワーカー触角特異的情報伝達物質運搬タンパク質の同定、機能解析、構造決定
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[Remarks] 石田裕幸, 名古屋大学大学院生命農学研究科20140328
