2013 Fiscal Year Final Research Report
Mechanism of selective transport in the retrograde traffic in the Golgi apparatus
| Project/Area Number |
23580105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NODA YOICHI 東京大学, 農学生命科学研究科, 助教 (90282699)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 微生物機能 / 小胞輸送 |
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| Research Abstract |
It is an essential step for cells that newly synthesized proteins are correctly targeted to the organelles where they function. We performed genetical and biochemical experiments to reveal the mechanisms for selective membrane transport between ER-Golgi using Saccharomyces cerevisiae, an excellent model eukaryotic cell. We identified a new cargo for the Erv41-Erv46 complex and found an ER-Golgi recycling membrane protein whose precise function was previously unknown as a new candidate of a cargo receptor protein.
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