2013 Fiscal Year Final Research Report
Identification of food components which regulate expression of genes related to metabolic syndrome
| Project/Area Number |
23580173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Saga University |
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Principal Investigator |
NAGAO Koji 佐賀大学, 農学部, 教授 (10336109)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脂肪組織 / 疾患遺伝子 / 食環境 / 生活習慣病 |
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| Research Abstract |
The metabolic syndrome is a cluster of metabolic disorders that contribute to increased cardiovascular morbidity and mortality. Especially, nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in metabolic syndrome. We found that the dietary intake of n-3 PUFA, n-3 polor lipid, extracts from plants alleviate NAFLD in obese, diabetic db/db mice. Our study demonstrated that those functional food components display at least two different physiological actions that alleviate NAFLD: one through the reduction of inflammatory damage by its suppression in MCP-1 production and the other through an increase of the serum adiponectin level and the prevention of visceral fat accumulation.
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[Journal Article] Structural Determination of Glucosylceramides in the Distillation Remnants of Shochu, the Japanese Traditional Liquor, and Its Production by Aspergillus kawachii2012
Author(s)
M. Hirata, T. Tsuge, L. Jayakody, Y. Urano, K. Takahashi, K. Sawada, S. Inaba, K. Nagao, H. Kitagaki
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Journal Title
J. Agrc. Food Chem
Volume: 60
Pages: 11473-11482
Peer Reviewed
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