2013 Fiscal Year Final Research Report
Prevention of chronic inflammation targeting angiopoietin-like protein 2
| Project/Area Number |
23580174
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMASAKI Masao 宮崎大学, 農学部, 准教授 (80381060)
SAKAKIBARA Yoichi 宮崎大学, 農学部, 教授 (90295197)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 慢性炎症 / アンジオポエチン様因子２ / β1インテグリン / α-リポ酸 |
|---|
| Research Abstract |
Recently chronic inflammation is regarded as causes of various diseases, such as diabetes, atherosclerosis and cancer. Angiopoietin-like protein 2 (ANGPTL2), a novel pro-inflammatory adipokine, has been reported to have important roles in the chronic inflammation and pathogenesis of various diseases. ANGPTL2 induces inflammatory signals via its receptor, integrin. In this study, we investigated the effect of alpha-lipoic acid (LA) on the expression of beta1-integrin in a human bladder cancer cell line and ANGPTL2 expression in 3T3-L1 murine adipocyte cell line. LA inhibited both beta1-integrin and ANGPTL2 expressions in a dose dependent manner, suggesting that LA might reduce chronic inflammation by inhibiting ANGPTL2 signaling pathway.
|
Research Products
(31 results)
-
-
-
-
[Journal Article] Induction of apoptotic cell death in HL-60 cells by jacaranda seed oil2013
Author(s)
Masao Yamasaki, Chihiro Motonaga, Marino Yokoyama, Aya Ikezaki, Tomoka Kakihara, Rintaro Hayasegawa, Kaede Yamasaki, Masanobu Sakono, Yoichi Sakakibara, Masahito Suiko, Kazuo Nishiyama
-
Journal Title
Journal of Oleo Science
Volume: 62(11)
Pages: 925-932
DOI
Peer Reviewed
-
-
-
-
-
[Journal Article] Jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice2012
Author(s)
Shinohara N, Ito J, Tsuduki T, Honma T, Kijima R, Sugawara S, Arai T, Yamasaki M, Ikezaki A, Yokoyama M, Nishiyama K, Nakagawa K, Miyazawa T, and Ikeda I.
-
Journal Title
Journal of Oleo Science
Volume: 61(8)
Pages: 433-441
DOI
Peer Reviewed
-
-
[Journal Article] Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo2012
Author(s)
Shinohara N, Tsuduki T, Ito J, Honma T, Kijima R, Sugawara S, Arai T, Yamasaki M, Ikezaki A, Yokoyama M, Nishiyama K, Nakagawa K, Miyazawa T, Ikeda I.
-
Journal Title
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
Volume: 1821(7)
Pages: 980-988
DOI
Peer Reviewed
-
[Journal Article] Effect of Highly Lipolyzed Goat Cheese on HL-60 Human Leukemia Cells : Antiproliferative Activity and Induction of Apoptotic DNA Damage2012
Author(s)
Yasuda, S., Kuwata, H., Kawamoto, K., Shirakawa, J., Atobe, S., Hoshi, Y., Yamasaki, M., Nishiyama, K., Tachibana,H., Yamada, K., Kobayashi,H., Igoshi, K.
-
Journal Title
J Dairy Sci
Volume: 95(5)
Pages: 2248-2260
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
