2014 Fiscal Year Final Research Report
Ovarian follicular cell dysfunction by lipopolysaccharide
| Project/Area Number |
23580383
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied animal science
|
|---|
| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011-04-28 – 2015-03-31
|
| Keywords | 卵巣機能 / ステロイドホルモン / 内毒素 / 顆粒層細胞 / 卵胞膜細胞 |
|---|
| Outline of Final Research Achievements |
In postpartum dairy cows, various inflammatory diseases depress reproductive performance. Lipopolysaccharide (LPS) derived from infections of the uterus or mammary gland with Gram-negative bacteria was shown to affect reproduction of dairy cow. LPS concentration detected in follicular fluid ranged from 0.2 to 2.0 EU/mL. In follicles with a high level of LPS (>0.5 EU/mL, n = 15), the concentration of E2 was lower and that of P4 was higher when compared to those in follicles with a low level of LPS (<0.5 EU/mL, n = 23). These findings suggest a possible mechanism of ovarian dysfunction and subsequent infertility in cows with endometritis.
|
| Free Research Field |
生殖科学
|
