2013 Fiscal Year Final Research Report
Synthesis of inner-core oligosaccharides of LPS and its protein conjugates for a definition of the epitope recognized by human antibodies
| Project/Area Number |
23580474
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | lipopolysaccharide / lipooligosaccharide / Kdo / conjugate / synthesis |
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| Research Abstract |
In this research, we successively achieved the synthesis of 9 type oligosaccharides, which are partial inner-core oligosaccarides of lipopolysaccharide/lipooligosaccharide produced by pathogenic gram-negative bacteria. And synthesized oligosaccharides were labeled with biotin and also conjugated to human serum albumin. These conjugates will be utilized for the definition of the epitope recognized by human antibody and the development of carbohydrate vaccine against pathogenic gram-negative bacterial infection.
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