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2013 Fiscal Year Final Research Report

Investigation of signaling mechanism for the anti-aging and the molecular basis of the immune senescence with ageing

Research Project

  • PDF
Project/Area Number 23580476
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied molecular and cellular biology
Research InstitutionNagasaki International University

Principal Investigator

FUJIKI Tsukasa  長崎国際大学, 薬学部, 講師 (00420612)

Project Period (FY) 2011 – 2013
Keywords細胞老化 / TERT / p38
Research Abstract

Their functions genes were extracted by the comprehensive analysis of senescence-associated genes involved in immune senescence, Involved light chain antibody genes (19 genes), leukemia-related factors (gene 3), intestinal immune antibody production factor of (1 gene) has become a clear and heavy chain. As a group of genes that increase in expression, immunoglobulin heavy chain-related genes (4 genes), adipose tissue development-related factors (2 genes), nerve memory associated calmodulin-binding factor, histone cluster-related genes, LDL (low density lipoprotein) scavenger gene, involvement colorectal cancer metastasis-related factors, and the like of (each one gene) becomes clear, changes were observed in the group of genes a wide range that suggest possible the association between age-related disease.

  • Research Products

    (5 results)

All 2013 2012 2010

All Presentation (5 results)

  • [Presentation] 加齢に伴うB細胞機能変化におけるMAPKp38の関与2013

    • Author(s)
      藤木司、片倉喜範、岸原健二
    • Organizer
      第30回日本薬学会九州支部大会
    • Place of Presentation
      長崎国際大学薬学部
    • Year and Date
      2013-12-08
  • [Presentation] 加齢に伴うB細胞機能変化におけるMAPKp38の関与2013

    • Author(s)
      藤木司、片倉喜範、岸原健二
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス
    • Year and Date
      2013-03-25
  • [Presentation] Function of MAPKp38 in aging-assosciated phenotypic changes of B cells2012

    • Author(s)
      藤木司、岸原健二、片倉喜範
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡マリンメッセ
    • Year and Date
      2012-12-11
  • [Presentation] 加齢に伴うB細胞機能変化におけるMAPKp38の関与2012

    • Author(s)
      藤木司、片倉喜範、岸原健二
    • Organizer
      第29回日本薬学会九州支部大会
    • Place of Presentation
      熊本大学薬学部
    • Year and Date
      2012-12-08
  • [Presentation] Function of MAPKp38 in aging-assosciated phenotypic changes of B cells2010

    • Author(s)
      藤木司、片倉喜範、岸原健二
    • Organizer
      2011第14回国際免疫学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2010-08-22

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Published: 2015-07-16  

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