2013 Fiscal Year Final Research Report
Development of Efficient Sensing Method for Targeting Proteins Based on Dehydrocondensing Reactions
| Project/Area Number |
23590004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kohei 金沢大学, 薬学系, 助教 (40583232)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 標識化反応 / トリアジン / 脱水縮合 / アミド / 標的タンパク質 / タンパク質探索 / 触媒反応 |
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| Research Abstract |
A modular method for affinity labeling (MoAL method), which is based on dehydrocondensing reactions in aqueous solvents and overcomes problems of conventional affinity labeling method, has been developed. In this research project, we succeeded in construction of highly efficient catalyst units for the MoAL method, development of high sensing method for trace amount of proteins, and detection of an unknown protein for some drugs by MoAL method.
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