2013 Fiscal Year Final Research Report
Development of SPECT probe for oxidative stress imaging
| Project/Area Number |
23590041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
SUZUKI Noriyuki 千葉大学, 薬学研究科(研究院), 准教授 (10376379)
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| Project Period (FY) |
2011 – 2013
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| Keywords | イメージング |
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| Research Abstract |
In vivo imaging have grown exponentially in these days, and SPECT has become indispensable in clinical use. Since SPECT imaging is more practical as routine clinical diagnostic procedures, the development of superior SPECT imaging probes had been required.
In this work, we focused on the development of SPECT probes for imaging of in vivo oxidative stress, the relationships between biological redox state and diseases relevant to oxidative stress such as cardiovascular disease, ischemic disease, diabetes mellitus and cancer. Ordinarily, the balance of reductant and oxidant in biological systems such as cells or organs is maintained appropriate state, and disturbance of the redox state is involved in pathogenic or precipitating mechanism of these diseases. Therefore we planed to visualize the redox state and the production levels of ROS.
The clinical application of these SPECT probes will provide significant knowledge on oxidative stress.
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Research Products
(17 results)
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[Journal Article] A new 2-aryl-1,4-naphthoquinone -1-oxime methyl ether compound induces microtubule depolymerization and subsequent apoptosis2012
Author(s)
H. Sato, R. Yamada, M. Yanagihara, H. Okuzawa, H. Iwata, A. Kurosawa, S. Ichinomiya, R. Suzuki, H. Okabe, T. Yano, T. Kumamoto, N. Suzuki, T. Ishikawa, K. Ueno
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Journal Title
J. Pharmacol. Sci
Volume: 118
Pages: 467-478
DOI
Peer Reviewed
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