2013 Fiscal Year Final Research Report
Formulation of novel functional dosage forms by spary congealing method.
| Project/Area Number |
23590047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
ITAI Shigeru 静岡県立大学, 薬学部, 教授 (80453059)
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| Co-Investigator(Kenkyū-buntansha) |
IWAO Yasunori 静岡県立大学, 薬学部, 助教 (30433022)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 噴霧凝固造粒 / 放出制御 / 苦味マスキング / 大腸デリバリー / 放出制御 |
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| Research Abstract |
By using spray congealing method, a taste masking technology with gastro-dissolvable polymer and low-melting-point material, a colon delivery system employing enteric polymer and low-melting-point material and a controlled release technology forming micropores dispersing sugars with various particle sizes were established. Furthermore, the optimization of formulation was carried out for each technology by applying multiple linear regression analysis. The spherical matrixes with optimum formula were manufactured by spray congealing method. As a result, each preparation exhibited intended release performance and both predictive and experimental data coincided with each other.
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[Journal Article] Investigation of internal structure of fine granules by microtomography using synchrotron X-ray radiation2013
Author(s)
Noguchi, S., Kajihara, R., Iwao, Y., Fujinami, Y., Suzuki, Y., Terada, Y., Uesugi, K., Miura, K., Itai, S.
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Journal Title
Int. J. Pharm
Volume: 445
Pages: 93-98
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