2013 Fiscal Year Final Research Report
Creaton of tablet database and visulalization of its internal structure
| Project/Area Number |
23590053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 錠剤データベース / ニューラルネットワーク / 自己組織化マップ / 主薬物性 / 品質特性 / 破壊強度 / 崩壊時間 / 比表面積 |
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| Research Abstract |
A tablet database was created in order for designing tablet formulations based on the quality by design concept. The contribution of active ingredients (APIs) to tablet properties such as tensile strength and disintegration time was clarified. Before investigating effects of APIs, the tablet base formulation (placebo tablet) was optimized according to an expanded simplex search. The optimal placebo tablet showed sufficient hardness and rapid disintegration. Model tablets were prepared by incorporating each of 14 kinds of active ingredients into the optimal placebo tablet, and then examined the tablet properties, including tensile strength and disintegration time. Based on the experimental data, an ensemble artificial neural network incorporating general regression analysis was conducted. A reliable model of the correlation between the physicochemical properties of the active ingredients and the tablet properties was thus constructed.
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[Presentation]2013
Author(s)
上原直人,岡田信人,林祥弘,大貫義則,小幡誉子,高山幸三
Organizer
第19回創剤フォーラム若手研究会
Place of Presentation
千葉
Year and Date
2013-12-07
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[Presentation]2013
Author(s)
乙黒沙織,松本智徳,林祥弘,大貫義則,小幡誉子,高山幸三
Organizer
第19回創剤フォーラム若手研究会
Place of Presentation
千葉
Year and Date
2013-12-07
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