2013 Fiscal Year Final Research Report
Study of the molecular mechanism underlying interaction between immune system and nervous system
| Project/Area Number |
23590086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Machiko 北海道医療大学, 薬学部, 准教授 (70229574)
TOGASHI Hiroko 北海道医療大学, 薬学部, 教授 (20113590)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アドレナリン受容体 / IL-33 / REDD1 / トランスグルタミナーゼ2 / ストレス |
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| Research Abstract |
In the present study, we examined the effects of the stress-related catecholamines adrenaline and noradrenaline on the functions of dendritic cells and macrophages. We found adrenoceptor-mediated increase in IL-33, REDD1, and transglutaminase 2 expressions by these cells. Because stress events activate the sympathetic nervous system and result in secretion of the catecholamines, adrenoceptor-mediated increase in these molecules might be associated with stress-related inflammatory disorders.
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