2013 Fiscal Year Final Research Report
Regulation of the adipose tissue functions by BMAL1
| Project/Area Number |
23590091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | BMAL1 / 脂肪組織 |
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| Research Abstract |
To understand the roles of the molecular clock system in the regulation of the adipose tissue functions, the mice specifically deleted Bmal1 gene, a core component of molecular clock system, in adipocytes (AKO mice) were established and analyzed in this study. Total food consumption of AKO mice was as much as that of control mice. However, the eating time of AKO mice was different from the control mice, and, as a result, A KO mice exhibited overweight. The effect of Bmal1 deficiency was observed in the localization of excess fat, i.e., the increase of the subcutaneous fatty tissue / epididymis fat tissue ratio was found in the AKO mice. The blood glucose level after the relatively brief fasting in AKO mice was significantly as lowered as compared to that in control mice. Also, the AKO mice showed increased glucose disposal rate. These results indicate that a molecular clock system controls systemic energy metabolism through the control of the adipose tissue functions.
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[Journal Article] The clock gene Brain and Muscle Arnt-Like Protein-1 (BMAL1) is involved in hair growth2013
Author(s)
Watabe, Y., Tomioka, M., Watabe, A.,Aihara, M., Shimba, S., and Inoue, H
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Journal Title
Arch. Dermatol. Res
Volume: 305
Pages: 755-761
Peer Reviewed
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[Journal Article] Clock genes influence gene expression in growth plate and endochondral ossification in mice2012
Author(s)
Takarada, T., Kodama, A., Hotta, S., Mieda, M., Shimba, S., Hinoi, E., and Yoneda, Y
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Journal Title
J Biol Chem
Volume: 287(43)
Pages: 36081-36095
Peer Reviewed
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[Journal Article] Diurnal expression of Dnmt3b mRNA in mouse liver is regulated by feeding and hepatic clockwork2012
Author(s)
Maekawa, F., Shimba, S., Takumi, S., Sano, T., Suzuki, T., Bao, J., Ohwada, M., Ehara, T., Ogawa, Y., and Nohara, K
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Journal Title
Epigenetics
Volume: 7(9)
Pages: 1046-1056
Peer Reviewed
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[Journal Article] Rhythmic nucleotide synthesis in the liver : Temporal segregation of metabolites Cell2012
Author(s)
Fustin, J.-M., Doi,M., Yamada, H., Komatsu, R., Shimba, S., and Okamura, H
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Journal Title
Reports
Volume: 1
Pages: 341-349
Peer Reviewed
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[Journal Article] Obesity alters the expression profile of clock genes in peripheral blood mononuclear cells2011
Author(s)
Tahira K, Ueno T, Fukuda N, Aoyama T, Tsunemi A, Matsumoto S, Nagura C, Matsumoto T, Soma M, Shimba S, Matsumoto Y
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Journal Title
Arch Med Sci
Volume: 7
Pages: 933-940
Peer Reviewed
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[Journal Article] Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation2011
Author(s)
Shimba, S., Ogawa, T., Hitosugi, S., Ichihashi, Y., Nakadaira, N., Kobayashi, M., Tezuka, M., Kosuge, Y., Ishige, K., Ito, Y., Komiyama, K., Okamatsu-Ogura, Y., Kimura, K., and Saito, M
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Journal Title
PLoS ONE
Volume: 6(9)
Pages: e25231
DOI
Peer Reviewed
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[Journal Article] CLOCK-controlled polyphonic regulations of circadian rhythms through canonical and non-canonical E-boxes
Author(s)
Yoshitane, H., Ozaki, H., Terajima, H., Du, NH., Suzuki, Y., Fujimori, T., Kosaka, N., Shimba, S., Sugano, S., Takagi, T., Iwasaki, W., and Fukada Y
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Journal Title
Mol Cell Biol
Volume: (in press)
Peer Reviewed
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