2013 Fiscal Year Final Research Report
Development of reagents regulating metabolism of ceramide and aranidonic acid and its application to lung disorder
| Project/Area Number |
23590106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDA Atsushi 千葉大学, 大学院薬学研究院, 教授 (80130029)
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| Project Period (FY) |
2011 – 2013
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| Keywords | セラミド / アラキドン酸 / 肺線維症 |
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| Research Abstract |
In this study, the following data were obtained: 1) activation of cPLA2alpha mediated by lactosylceramide in TNFalpha-stimulated cells, 2) development of new ceramide analogs inhibiting cPLA2alpha activity, 3) activation of alkaline caramidase by c-Src, 4) an interaction between cellular cholesterol and ceramide metabolites.
In addition, we showed 5) dual regulation of TGFbeta-induced fibrosis by S1P: stimulation by S1P3 receptor activation and inhibition by S1P1 receptor activation, and 6) an inhibitory effect of cyclosporin on TGFbeta-induced fibrosis in human lung fibroblasts.
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