Elucidation of drug resistance mechanism against influenza virus

2015 Fiscal Year Final Research Report

• Project/Area Number: 23590145
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: Tagawa Yuko (坂井優子) 東京大学, 医科学研究所, 助手 (40178538)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Keywords: インフルエンザ / 薬剤耐性 / 新型インフルエンザ / 抗インフルエンザ薬 / ノイラミニダーゼ阻害薬 / 小児ぜんそく / ステロイド剤

Outline of Final Research Achievements

In clinical specimens from hundreds of patients who infected with Influenza virus (A/H1N1pdm) and received anti-influenza drug therapy, quantifying the virus and analyzing the nucleotide sequences of the drug-resistant mutant viruses were carried out. It was succeeded to show that neuraminidase inhibitor was more effective to viral shedding of H1N1pdm than that of H3N2 or B-type, but resistance mutation was observed in 10~30%. In addition, the steroid treatment for immunosuppression resulted in the viral shedding period was longer and emerging the drug-resistant virus was also remain in the long period in the case of the H1N1pdm-infected children.

Free Research Field

ウイルス学