2013 Fiscal Year Final Research Report
Development of risk evaluation method for xenobiotics based on the interindividual differences of drug-metabolizing enzymes
| Project/Area Number |
23590148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Yokohama College of Pharmacy (2013)
Okayama University (2011-2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARIMATSU Shizuo 岡山大学, 大学院医歯薬学総合研究科, 教授 (20113037)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 異物代謝酵素 / シトクロムP450 / UDP-グルクロン酸転移酵素 / フタル酸エステル類 / iPS細胞 |
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| Research Abstract |
The purpose of this study was to develop risk evaluation method for environmental pollutants such as endocrine-disruptors and sick-building syndrome substances. The finding in this study suggest that diester phthalate hydrolysis activities in human liver microsomes depend on the chemical structure, and that the expression and inducibility of UGT in iPS cell-derived hepatocyte-like cells are similar that of human livers.
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Research Products
(9 results)
