2013 Fiscal Year Final Research Report
Effect of reduced renal function on homocysteine metabolism
| Project/Area Number |
23590202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIDA Kimiyoshi 東京薬科大学, 薬学部, 教授 (80183169)
SHINOHARA Yoshihiko 東京薬科大学, 薬学部, 教授 (00154229)
NAKAMURA Makiko 東京薬科大学, 薬学部, 助教 (80447557)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ホモシステイン / メチオニン / メチル基転移 / 安定同位体 / 腎不全 / GC-MS / 代謝フラックス |
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| Research Abstract |
Hyperhomocysteinemia is a risk factor for cardiovascular diseases and occurs frequently in end-stage renal disease, but the pathogenesis is poorly understood. The plasma homocysteine concentration represents the balance between its entry and removal from the circulation. This study is conducted to clarify whether hyperhomocysteinemia in renal disease is due to increased entry or decreased removal. The result of the present study showed that the conversion of homocysteine to methionine was substantially decreased in the 3/4-nephrectomized rats. Decreased remethylation may explain hyperhomocysteinemia in renal disease.
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