2013 Fiscal Year Final Research Report
Development of novel pro-drugs based on the bile acid as a core compound
| Project/Area Number |
23590209
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEGAWA Shigeo 近畿大学, 薬学部, 教授 (90111301)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 胆汁酸 / N-アセチルシステイン / プロドラッグ / 肝・胆・消化機能改善薬 / 液体クロマトグラフィー / 質量分析法 |
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| Research Abstract |
We demonstrated that N-acetylcysteine conjugate of ursodeoxycholic acid (UDCA-NAC) was hydrolyzed and circulated in body as UDCA after administration by injection via jugular vein, while UDCA-NAC converted to NAC-sulfate di-conjugate by rat liver cytosolic fraction. Furthermore, UDCA-NAC was shown to inhibit the increase of liver disease marker enzymes, AST and ALT, in serum of acetaminophen-induced liver injury rats. These results showed that UDCA-NAC is useful as a prodrug of the new liver, bile, digestive function improving agent.
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[Journal Article] A novel varanic acid epimer—(24R, 25S)-3α,7α,12α,24-tetrahydroxy-5β- cholestan- 27-oic acid—is a major biliary bile acid in two varanid lizards and the Gila monster2012
Author(s)
Hagey LR, Ogawa S, Kato N, Satoh née Okihara R, Une M, Mitamura K, Ikegawa S, Hofmann AF, Iida T
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Journal Title
Steroids
Volume: 77
Pages: 1510-1521
DOI
Peer Reviewed
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